畜牧兽医学报2018，Vol.49Issue(3)：515-524,10.DOI:10.11843/j.issn.0366-6964.2018.03.007
FGF7亚家族在小鼠毛囊第一生长周期的表达
Expression Profile of Fibroblast Growth Factor 7 Sub-family in the First Hair Follicle Cycle of Mice Skin
摘要
Abstract
The aim of this study was to investigate the expression patterns of fibroblast growth factor (FGF) 7 subfamily (FGF7,FGF10 and FGF22) in the first hair follicle growth cycle of mice.The Real-time PCR,Western blot and immunohistochemistry were adopted to study the expression of FGF7/FGF10/FGF22 mRNA and protein in mice back skin on 1,3,5,8,16,18,20,23 postnatal days.The results of immunohistochemistry showed that FGF7 protein was mainly located in the inner root sheath and epidermal;FGF10 and FGF22 were widely located in various structure of hair follicle.The results of real-time PCR,Western blot as well as immunohistochemistry showed that the FGF7 level was the lowest in catagen(16 d).And relative level of FGF7 was significantly increased in telogen (18 d) and anagen (1-8,20-23 d),compared to its expression in catagen (16 d) (P＜0.05,P＜0.01).The FGF10 level was the lowest in the end of anagen (8 d).And the relative level of FGF10 was significantly increased in prophase and metaphase of anagen (1-5,20-23 d),catagen (16 d) and telogen (18 d) compared to its expression in the end of anagen (8 d) (P＜0.05,P＜0.01).The FGF22 level was the highest in catagen (16 d).And relative level of FGF22 was significantly decreased in telogen (18 d) and anagen (1-8,20-23 d) compared to its expression in the catagen (16 d) (P＜0.05;P＜0.01).These results suggested that FGF7 and FGF10 might play an important role in inducing hair follicle into the new cycle during the development of hair follicle,and FGF22 might have an important effect on the induction of hair follicles into catagen.关键词
FGF7/10/22/小鼠/背部皮肤/毛囊/第一生长周期Key words
FGF7/FGF10/FGF22/mice/back skin/hair follicle/the first growth cycle分类
生物科学引用本文复制引用
牛姝,程笳琪,高淑媛,曹校瑞,吴晋强,陆娜,闫瑞琴,赫晓燕..FGF7亚家族在小鼠毛囊第一生长周期的表达[J].畜牧兽医学报,2018,49(3):515-524,10.基金项目
国家自然科学基金项目(31172283) （31172283）
