中国医疗设备2018，Vol.33Issue(4)：22-28,7.DOI:10.3969/j.issn.1674-1633.2018.04.006
基于上臂袖带振荡波估测动脉僵硬度的理论方法及临床实验
Theoretical Method and Clinical Experiments for Estimating Arterial Stiffness Based on Upper-Arm Cuff Oscillometric Wave
摘要
Abstract
Objective To examine the validity of an upper-arm cuff-based pulse wave device (PASESA AVE-1500) on assessing central arterial stiffness based on oscillometric waves, and analyze the related influential factors. Methods A computational model of the cardiovascular system coupled with an upper-arm oscillometric cuff was constructed and applied to simulate the measurement process of the pulse wave device. With the model, a theoretical study for assessing central arterial stiffness based on the characteristics of cuff oscillometric wave was performed, followed by a series of numerical experiments aimed to quantify the sensitivity of the assessment to various cardiovascular parameters. Furthermore, the validity of the pulse wave device was examined by clinical experiments. Results The computational model-based theoretical study revealed that the ratio of the second valley to the first peak (|V2|/|P1|) on the time-differentiated cuff wave correlated positively with the stiffness of central arteries. Subsequent numerical experiments showed that |V2|/|P1| increased with the impairment of cardiac systolic function, but was relatively less influenced by the total peripheral vascular resistance and the stiffness of the brachial artery. The clinical study demonstrated that the measured pulse velocity index (AVI) differed significantly between the patient group with cardiovascular diseases (n=68) and the healthy subject group (n=170) (P<0.0001), which was consistent with the inter-group difference observed for brachial-ankle pulse wave velocity (baPWV) (P<0.0001). In addition, AVI was found to correlate significantly with both baPWV (r=0.656, P<0.0001) and age (r=0.525, P<0.0001). Conclusion The mechanical property of central arteries can be obtained by analyzing the oscillometric wave of an upper-arm cuff, which makes it possible to noninvasively and rapidly assess central arterial stiffness.关键词
上臂袖带振荡波/动脉僵硬度/循环系统—袖带耦合模型/动脉脉波检测仪Key words
oscillometric wave of upper-arm cuff/arterial stiffness/computational model of the circulatory system coupled with a cuff/upper-arm cuff-based pulse wave device分类
生物科学引用本文复制引用
张絮洁,章亚平,殷兆芳,覃开蓉,梁夫友..基于上臂袖带振荡波估测动脉僵硬度的理论方法及临床实验[J].中国医疗设备,2018,33(4):22-28,7.基金项目
国家自然科学基金(31370948). （31370948）
