Abstract
Objective To observe the effects of bisoprolol in patients with pulmonary heart disease complicated with arrhythmia,and analyze its effects on lung function,blood gas index and CRP,BNP. Methods Ninety-six patients with pul-monary heart disease complicated with arrhythmia who were treated in hospital from March 2015 to March 2016 were selected. Patients were divided into the observation group(48 cases) and control group(48 cases). The patients of control group were treated with dilthiazole,while the patients of observation group were treated with bisoprolol. Compare the clinical effect,safety and changes of the lung function, blood gas index, pulmonary artery systolic pressure,6 min walking distance, heart rate, CRP and BNP levels of the two groups. Results After the appropriate treatment, the total effective rate of the observation group was significantly better than those of the control group (χ2= 4.800; P= 0.028); The FEV1, FEV1%, PaO2, VC levels of the observation group were significantly higher than those of the control group,and the PaCO2,PH levels of the ob-servation group were significantly lower than those of the control group (t= 2.503, t=12.617, t=4.823, t=1.739, t=2.655,t=1.781;P= 0.007,P=0.000,P=0.000,P=0.043,P=0.005,P=0.039);The 6 min walking distance of the observation group were significantly longer than those of the control group,and the pulmonary artery SBP,HR,BNP levels of the observation group were significantly lower than those of the control group (t= 14.312, t=7.419, t=16.917, t=57.221;P= 0.000,P=0.000,P=0.000,P=0.000);The CRP,IL-6,TNF-α levels of the observation group were sig-nificantly lower than those of the control group (t= 16.379, t=1.921, t=4.625; P= 0.000, P=0.000, P=0.000);The number of hospitalized again and the number of dead of the observation group were significantly lower than those of the control group(χ2= 5.056;P= 0.025). Conclusion The effect of bisoprolol in pulmonary heart disease complicated with arrhythmia is good. It can improve the blood gas and lung function,reduce inflammatory symptoms,and help to improve the patient's mobility and quality of life,which makes it worthy of clinical application.关键词
比索洛尔/肺源性心脏病/心律失常/C反应蛋白/脑钠肽Key words
Bisoprolol/Pulmonary heart disease/Arrhythmia/C reactive protein/Brain natriuretic peptide
