疑难病杂志2018，Vol.17Issue(4)：387-390,4.DOI:10.3969/j.issn.1671-6450.2018.04.015
TSH、TPOAb水平对桥本甲状腺炎与甲状腺乳头状癌的鉴别诊断价值
The differential diagnostic value of TSH and TPOAb levels in Hashimoto's thyroiditis and papillary thyroid carcinoma
摘要
Abstract
Objective To investigate the diagnostic value of thyroid stimulating hormone(TSH) and anti-thyroid per-oxidase antibody (TPOAb) in Hashimoto's thyroiditis (HT) and papillary thyroid carcinoma (PTC). Methods Two hun-dred and forty-four patients came to First Affiliated Hospital of Xinjiang Medical University for treatment of thyroid diseases from February 2015 to March 2017 were grouped according to the categories of diseases;and thyroid benign tumor group were 153 cases,PTC group were 65 cases,HT group were 26 cases. Thyroid function and TPOAb levels of each group were detec-ted and compared,TSH abnormalities and TPOAb positive cases were analyzed and compared,and the value of TSH and TPO-Ab in differential diagnosis of HT was evaluated. Results The detection levels of T3,T4,FT 3 and FT4in thyroid function were not significantly different among the three groups (F=2.034, F=1.847, F=1.066, F=0.896,P=0.278, P=0.324,P=0.403,P=0.784). Compared with the level of TSH and TPOAb,the HT group was(4.90 ± 0.95)mIU/L and 84.52 (24.64,1708.50) IU/ml,which was the highest,and followed by the PTC group and the thyroid benign tumor group, there was obvious difference among the groups(F=8.211,F=17.541,P=0.046,P=0.018). Compared with TSH abnor-mal rate and TPOAb positive rate of the three groups,the HT group was 61.54% and 50%,which was the highest,and fol-lowed by the PTC group and the thyroid benign tumor group,there was obvious difference among the groups(F=19.982,F=29.047,P=0.015,P=0.007). TSH and TPOAb differential diagnosis of HT and PTC cut-off values were 4.25 mIU/L and 75.50 IU/ml,the sensitivity were 80.20% and 74.51%,specificity were 70.40% and 68.50%,Youden index were 0.506 and 0.430 respectively. Conclusion TSH and TPOAb play an important role in differential diagnosis of Hashimoto's thyroidi-tis and papillary thyroid carcinoma,which is worthy of further study.关键词
促甲状腺激素/过氧化物酶抗体/桥本甲状腺炎/甲状腺乳头状癌/鉴别诊断Key words
Thyroid stimulating hormone/Peroxidase antibody/Hashimoto's thyroiditis/Papillary thyroid carcino-ma/Differential diagnosis引用本文复制引用
吾甫尔·依马尔,王护国,哈力木拉提,李新喜..TSH、TPOAb水平对桥本甲状腺炎与甲状腺乳头状癌的鉴别诊断价值[J].疑难病杂志,2018,17(4):387-390,4.基金项目
新疆重大疾病医学重点实验室开放课题(SKLIB-XJMDR-2016-6) （SKLIB-XJMDR-2016-6）
