疑难病杂志2018，Vol.17Issue(4)：420-423,4.DOI:10.3969/j.issn.1671-6450.2018.04.025
ADAM33基因多态性对慢性阻塞性肺疾病肺功能影响的研究进展
The research progress of the association between polymorphisms in ADAM33 gene with COPD and lung function
摘要
Abstract
The pathogenesis of COPD is a multifactorial process including inflammatory cell profile, relevant with individual factors,environmental factors and genetic factors. ADAM33 gene has selectively expressed in mesenchymal cells, participates in the airway remodeling process, which has been identified as an asthma susceptible gene and high reactivity related genes. Recent studies revealed that single nucleotide polymorphisms (SNPs) within ADAM33 increased the suscepti-bility to COPD through changing the airway inflammatory process and lung function by making organisms susceptible to certain environmental factor. Therefore,in order to understand the role of ADAM33 gene in the process of lung function decline in COPD,contribute to the treatment of this disease, ADAM33' SNPS and it's the impact on COPD pulmonary function reviewed.关键词
ADAM33/慢性阻塞性肺疾病/基因多态性/肺功能Key words
ADAM33/Chronic obstructive pulmonary disease/Single nucleotide polymorphism/Lung function引用本文复制引用
邵路,贾艳云..ADAM33基因多态性对慢性阻塞性肺疾病肺功能影响的研究进展[J].疑难病杂志,2018,17(4):420-423,4.基金项目
黑龙江省青年科学基金项目(QC2011C047) （QC2011C047）
