应用化学2018，Vol.35Issue(4)：401-409,9.DOI:10.11944/j.issn.1000-0518.2018.04.170463
pH和温度敏感型聚合物荧光探针的合成及应用
Synthesis and Characterization of pH and Temperature Sensitive Polymeric Fluorescent Probe
摘要
Abstract
A pH and thermo-responsive fluorescent polymeric sensor Poly(POSS-NI-NIPAM)was synthesized from naphthalimide(NI),N-isopropyl acrylamide(NIPAM)and polyhedral oligomeric silsesquioxane(POSS) as raw materials by the reversible addition-fragmentation chain transfer polymerization(RAFT).The pH and thermo-responsive properties of Poly(POSS-NI-NIPAM)were characterized by nuclear magnetic resonance spectroscopy(NMR),fluorescence emission spectrometer and mass spectrometry(MS).The results show that Poly(POSS-NI-NIPAM)shows obvious fluorescence changes in the range of pH 5.8~8.0 with a reversible performance.The high sensitivity for pH/temperature makes Poly(POSS-NI-NIPAM)as a promising fluorescent probe for the detection of intracellular pH/temperature in living cells.关键词
聚合物荧光探针/pH敏感/温度敏感/多面体笼状硅氧烷Key words
polymeric fluorescent probe/pH sensitivity/temperature sensitivity/polyhedral oligomeric silsesquioxane分类
化学化工引用本文复制引用
陈帆,郭志前,朱为宏..pH和温度敏感型聚合物荧光探针的合成及应用[J].应用化学,2018,35(4):401-409,9.基金项目
国家自然科学基金(21622602,21325625)项目资助 Supported by the National Natural Science Foundation of China(No.21622602,No.21325625), （21622602,21325625）
