中国临床药理学与治疗学2018，Vol.23Issue(2)：154-158,5.DOI:10.12092/j.issn.1009-2501.2018.02.007
OCT2、MDR1基因多态性与婴幼儿万古霉素血药浓度及临床疗效的相关性研究
Effects of OCT2 and MDR1 gene polymorphisms on vancomycin concentration and clinical efficacy in infants
摘要
Abstract
AIM:To study the effects of organic cation transporter 2 (OCT2) and multidrug resistance gene 1 (MDR1) gene polymorphisms on plasma concentration and clinical efficacy of vancomycin in infants.METHODS:Ninety-one infants that treated with vancomycin were recruited.The plasma concentrations of vancomycin were measured by enzyme multiplied immunoassay technique.The genotypes of OCT2 G808T (rs316019) and MDR1 C3435T (rs1045642) were determined by polymerase chain reaction followed with direct sequencing.The association between different genotypes and the concentrations and clinical efficacy of vancomycin were analyzed.RESULTS:There were 16.5％ patients which the concentration reached 10-20 μg/ mL.The curative effect of 5-＜ 10 μg/mL (88％)and 10-20 μg/mL (93.3％) were significant higher than that of ＜ 5 μg/mL (44％) (P ＜ 0.05);and the curative effect of 5-＜ 10 μg/mL and 10-20 μg/mL were similar.The plasma concentration (10.15 ± 2.35) μg/mL and concentration/dose values (0.98 ± 0.27) μg · mL-1 · mg-1 · kg of vancomycin in infants with OCT2 TT genotype were significantly increased than that of OCT2 GG genotypes (6.92 ± 2.83) μg/mL,(0.59±0.22) μg· mL-1· mg-1 kg (P ＜ 0.05).Meanwhile,the clinical efficacy of vancomycin in TF genotype (100％) was higher than that in GG genotype (73.2％) (P ＜ 0.05).However,the concentration and clinical efficacy of vancomycin in the infants with mutant type and wild type of MDR1 C3435T were similar (P ＞ 0.05).CONCLUSION:OCT2 G808T polymorphism is associated with the plasma concentrations and clinical efficacy of vancomycin in infants.关键词
万古霉素/药物转运体/基因多态性/血药浓度/婴幼儿Key words
vancomycin/drug transporter/polymorphisms/plasma concentration/infant分类
医药卫生引用本文复制引用
陈曜曜,史道华,刘光华,牛培广,刘柏晨..OCT2、MDR1基因多态性与婴幼儿万古霉素血药浓度及临床疗效的相关性研究[J].中国临床药理学与治疗学,2018,23(2):154-158,5.基金项目
福建省妇幼保健院科研课题(妇保院研15-15) （妇保院研15-15）
