中国临床药理学与治疗学2018，Vol.23Issue(2)：159-164,6.DOI:10.12092/j.issn.1009-2501.2018.02.008
细胞色素P4501A1基因多态性对奥沙利铂联合卡培他滨方案治疗结直肠癌患者临床疗效的影响
Influence of CYP1A1 polymorphism on clinical outcomes of CRC patients treated by oxaliplatin plus capecitabine
肖鹏 1梅家转 1白桦 1栗敏 1刘桂举 1李瑞君 1沈杰2
作者信息
- 1. 郑州人民医院肿瘤科,郑州450000,河南
- 2. 皖南医学院弋矶山医院临床药学部,芜湖241001,安徽
- 折叠
摘要
Abstract
AIM:To investigate whether gene variants of cytochrome P450 (CYP450) affected clinical outcomes of oxaliplatin plus capecitabine in colorectal cancer (CRC).METHODS:Sixty-nine CRC patients who were treated with oxaliplatin plus capecitabine were included in this study.And 79 SNPs in CYP450,whose minor allele frequency (MAF) were ＞ 10％ were genotyped.Association between the SNP and clinical outcomes were analyzed.RESULTS:Only one SNP,CYP1A1 rs1048943 was significantly associated with PFS (P =0.000 3).Multivariate analysis confirmed its prognostic significance for PFS (P =0.004).CONCLUSION:CYP1A1 rs1048943 polymorphism is probably a potential prognostic marker for survival outcome treated with oxaliplatin plus capecitabine chemotherapy in CRC patients.关键词
结直肠癌/细胞色素P450/多态性Key words
colorectal cancer/CYP450/polymorphism分类
医药卫生引用本文复制引用
肖鹏,梅家转,白桦,栗敏,刘桂举,李瑞君,沈杰..细胞色素P4501A1基因多态性对奥沙利铂联合卡培他滨方案治疗结直肠癌患者临床疗效的影响[J].中国临床药理学与治疗学,2018,23(2):159-164,6.
