中国临床药理学与治疗学2018，Vol.23Issue(2)：165-169,5.DOI:10.12092/j.issn.1009-2501.2018.02.009
右美托咪定复合盐酸羟考酮术后镇痛对胃肠肿瘤病人睡眠质量的影响
Effects of oxycodone hydrochloride combined with dexmedetomidine postoperative analgesia on sleep quality of patients with gastrointestinal tumors
摘要
Abstract
AIM:To evaluate the effects of hydrochloride oxycodone combined with dexmedetomidine postoperative analgesia on sleep quality of patients with gastrointestinal tumors.METHODS:Sixty ASA Ⅰ or Ⅱ patients aged 49-74 year with BMI of 17-24 kg/m2 undergoing laparoscopic resection of gastrointestinal tumors were randomly divided into 3 groups (n =20 in each group):group Ⅰ oxycodone (group O),dexmedetomidine 0.05 μg ·kg-1 · h-1 combined with oxycodone group (group D1),dexmedetomidine 0.1 μg · kg-1 · h-1 combined with oxycodone group (group D2).In O,D1,and D2 groups,the PCIA solution contained oxycodone 50 mg,oxycodone 50 mg plus dexmedetomidine 0.05 μg · kg-1 · h-1,and oxycodone 50 mg plus dexmedetomidine 0.1 μg · kg-1 · h-1 in 100 mL of 0.9％ normal saline,respectively.The PCIA pump was set up to deliver a 0.5 mL bolus dose with a 15-min lockout interval and background infusion at 2 mL/h.VAS score was maintained ≤4.Polysomnography measures were performed the night before surgery (T0),the first night after surgery (T1),and the second night after surgery (T2),and recorded the sleep efficiency index (SEI),arousal index (AI),the percent of rapid eye-movement (REM).Patients' satisfaction and the occurrence of adverse reactions such as hypotension,bradycardia,somnolence,dizziness,vomiting were also recorded.RESULTS:Compared with T0,SEI were significantly decreased and AI were significantly increased in T1 of three groups and T2 of group O (P ＜ 0.05);Compared with group O,SEI were significantly increased and AI were significantly decreased in group D1 and D2 (P ＜ 0.05),the patients' satisfaction and the occurrence of hypotension were significantly increased,the occurrence of vomiting was significantly decreased (P ＜ 0.05);Compared with group D1,the occurrence of hypotension,bradycardia,somnolence was significantly increased in group D2 (P ＜0.05).CONCLUSION:Postoperative analgesia with small dose of dexmedetomidine combined with oxycodone hydrochloride can significantly improve the sleep quality of patients with gastrointestinal tumors,with fewer occurrence of hypotension and better patients' satisfaction.关键词
右美托咪定/盐酸羟考酮/睡眠质量/镇痛Key words
dexmedetomidine/hydrochloride oxycodone/sleep quality/analgesia分类
医药卫生引用本文复制引用
王俊,蒋宗明,郑君刚,曹刚,黄长顺,卢子会,季一勤..右美托咪定复合盐酸羟考酮术后镇痛对胃肠肿瘤病人睡眠质量的影响[J].中国临床药理学与治疗学,2018,23(2):165-169,5.基金项目
浙江省绍兴市卫计委青年科技计划(2016QN004) （2016QN004）
浙江省医学会临床科研基金项目(2015ZYC-A51) （2015ZYC-A51）
