中国临床药理学与治疗学2018，Vol.23Issue(2)：175-179,5.DOI:10.12092/j.issn.1009-2501.2018.02.011
精准麻醉对机器人辅助腹腔镜前列腺癌根治术患者围术期细胞免疫功能的影响
Effects of precise anesthesia on perioperative cellular immune function in patients undergoing robot-assisted laparoscopic radical prostatectomy
摘要
Abstract
AIM:To evaluate the effects of precise anesthesia on perioperative cellular immune function in patients undergoing robot-assisted laparoscopic radical prostatectomy.METHODS:Fifty-six patients who underwent robot-assisted laparoscopic radical prostatectomy were randomly allocated into control group (A,n =28) and experiment group (B,n =28).In group A,propofol was infused to achieve the BIS value of 45-55,and the muscle relaxation was monitored to conduct closed-loop infusion of cisatracurium,liquid input were monitored and managed by Vigileo.In group B,the depth of anesthetic with the patients'vital signs according to anesthetists' experience was regulated.Venus blood were sampled respectively before anesthesia induction (T0),after induction of anesthesia before surgery(T1),1 h after anesthesia(T2),2 h(T3),24 h (T4),72 h after operation (T5).The percentages of T lymphocyte subsets (CD3+,CD4+,CD8+,CD4+/CD8+,FoxP3-Treg ratio) and NK ratio were detected by flow cytometry.RESULTS:Compared with group B,CD4 + at T1,T2,T4 and T5 were higher in group A,NK cells at T2 were higher in group A (P ＜ 0.05).Compared with T0,CD4 + and CD4 +/CD8 + increased at T1 in group A,CD4 + and NK cells were decreased at T1 in group B (P ＜0.05);CD3+,CD4+,CD8+,CD4+/ CD8 + and NK cells were significantly decreased at T2 in group B (P ＜ 0.05);CD3 +,CD4 + decreased significantly at T3 in both group A and group B and CD4 +/CD8 + decreased in group B (P ＜ 0.05);CD4 + increased in group A and the level of Treg both in A and B groups were decreased significantly at T5 (P ＜ 0.05).CONCLUSION:Precise anesthesia can reduce the inhibitory effect of general anesthesia on cellular immune function in patients undergoing robot-assisted laparoscopic radical prostatectomy.关键词
机器人/腹腔镜/前列腺癌/细胞免疫功能Key words
robot/laparoscopic/prostatic cancer/cellular immune function分类
医药卫生引用本文复制引用
王婷,陈珂,周长平,王义桥,鲁显福,李元海..精准麻醉对机器人辅助腹腔镜前列腺癌根治术患者围术期细胞免疫功能的影响[J].中国临床药理学与治疗学,2018,23(2):175-179,5.基金项目
安徽省公益性技术研究联动项目(1704f0804021) （1704f0804021）
