中国临床药理学与治疗学2018，Vol.23Issue(2)：199-204,6.DOI:10.12092/j.issn.1009-2501.2018.02.016
临床药学服务对幽门螺杆菌阳性消化性溃疡患者用药依从性及治疗效果的影响分析
Influence of clinical pharmaceutical care on medication compliance and treatment effect in Helicobacter pylori positive peptic ulcer outpatients
摘要
Abstract
AIM:To assess the influence of clinical pharmaceutical care on medication compliance and treatment effect in Helicobacter pylori (H.pylori) eradication in outpatients with peptic ulcer.METHODS:Ninety-six outpatients with H.pylori positive peptic ulcer from July 2015 to June 2016 were prospectively collected and were randomly divided into control group and intervention group.Patients in the control group were given the traditional outpatient service.The intervention group patients received pharmaceutical education and follow-up by clinical pharmacist.Medication compliance and gastrointestinal symptom were assessed in both groups before and after H.pylori eradication therapy.H.pylori eradication rates of all patients were tested by 14C urea breath test after the end of stopping all medicines for at least 4 weeks.RESULTS:The score and the improvement of compliance with medication of intervention group patients were significantly higher than those of the control group (3.73 vs.2.58,1.71 vs.0.44,P＜0.01).81.25％ of patients in intervention group and 60.42％ of patients in control group took all prescribed doses.The difference was statistically different (P ＜ 0.05).Forty-four patients of the intervention group and thirty-six patients in the control group reported less gastrointestinal symptoms (91.67％ vs.75.00％,P ＜ 0.05).The H.pylori eradication rate of the intervention group was significantly higher than that of the control group (91.67％ vs.72.92％,P ＜ 0.05).CONCLUSION:Clinical pharmaceutical care has a significant effect on H.pylori eradication rate,medication compliance and the improvement of gastrointestinal symptom.关键词
临床药学服务/根除幽门螺杆菌/消化性溃疡/用药依从性Key words
clinical pharmaceutical care/Helicobacter pylori eradication/peptic ulcer/medication compliance分类
医药卫生引用本文复制引用
李静静,虞燕霞,唐莲,张金坤,余强,尚尔宁..临床药学服务对幽门螺杆菌阳性消化性溃疡患者用药依从性及治疗效果的影响分析[J].中国临床药理学与治疗学,2018,23(2):199-204,6.基金项目
江苏省药学会-奥赛康医院药学科研项目(201408) （201408）
