中国临床药理学与治疗学2018，Vol.23Issue(2)：205-210,6.DOI:10.12092/j.issn.1009-2501.2018.02.017
哺乳动物细胞自噬关键节点及相关药物的研究进展
Research progress of the key targets of autophagy and related drugs in mammalian cells
摘要
Abstract
Autophagy is a catabolic process for the degradation and recycling of macromolecules and organelles,which is activated during stress conditions.It plays an important role in maintain a homeostasis in the cell,and is closely related to many diseases,especially the development of tumor,which makes researchers pay more attention on control autophagy as a target of new drug development and clinical application.However,the mechanism of autophagy process is very complicated.This article reviews the research progress of crucial targets mTOR,ULK,Beclin 1,Atg12 connection system,LC3 lipid connection system and p62/SQSM1,which are involved in autophagy signaling pathways and its related drugs.关键词
自噬/靶点/信号通路/药物研发Key words
autophagy/target/signaling pathway/drug development分类
医药卫生引用本文复制引用
王欣,陈宝强,李红玉..哺乳动物细胞自噬关键节点及相关药物的研究进展[J].中国临床药理学与治疗学,2018,23(2):205-210,6.基金项目
国家自然科学基金项目(81403145,81560715) （81403145,81560715）
“重大新药创制”科技重大专项子项目(2015ZX09501-004-003-008) （2015ZX09501-004-003-008）
