中国临床药理学与治疗学2018，Vol.23Issue(2)：223-229,7.DOI:10.12092/j.issn.1009-2501.2018.02.020
类风湿关节炎下转运体表达及活性的变化
Changes of transporters expression and activity in rheumatoid arthritis
摘要
Abstract
Inflammatory disease state will release a large number of inflammatory cytokines,and accompanied by drug transporters expression and activity changes.Drug transporters are present in various tissues and have an important role in drug absorption,distribution,and elimination.Expression and activity changes will affect the body's plasma concentration,accumulation,the effectiveness of drug treatment,and even produce multidrug resistance,drug-drug interactions and so on.Rheumatoid arthritis is a common inflammatory disease that releases a large number of inflammatory cytokines,with changes in expression and activity of the transporters,which affects the therapeutic effect and changes the expression and activity of the drug transporters.This review summarizes the knowledge on the roles of transporters in rheumatoid arthritis in order to provide a new direction for the treatment of rheumatoid arthritis.关键词
类风湿关节炎/SLC转运体/ABC转运体Key words
rheumatoid arthritis/SLC transporters/ABC transporters分类
医药卫生引用本文复制引用
杜娟,徐玲燕,吴伟,沈青青,江振洲,张陆勇,黄鑫..类风湿关节炎下转运体表达及活性的变化[J].中国临床药理学与治疗学,2018,23(2):223-229,7.基金项目
国家自然科学基金面上项目(81673684) （81673684）
国家自然科学基金青年项目(81303301) （81303301）
江苏省研究生培养创新工程(KYCX17-0718) （KYCX17-0718）
国家自然科学基金重大国际(地区)合作研究项目(81320108029) （地区）
