中国临床药理学与治疗学2018，Vol.23Issue(2)：230-234,5.DOI:10.12092/j.issn.1009-2501.2018.02.021
新型抑制性细胞因子IL-35与支气管哮喘的研究进展
Research progress of the association between new inhibitory cytokines il-35 and bronchial asthma
摘要
Abstract
Asthma,while its pathogenesis remains unclear,is the most common chronic respiratory disease influenced by many factors including genetic and environmental influences.Classical theories believe that T helper cells(Th) 1/Th2 cells are unbalanced,which further decrease Thl cells response,and increase Th2 cells response.They cause allergen specific IgE secretion,airway eosinophils (EOS) infiltration,chronic airway inflammation and airway hyper-responsiveness (AHR).The findings of regulatory T cells (Tregs) and Thl7 renew the understanding of the inflammatory mechanisms of asthma.The pathogenesis is no longer confined to the Thl/Th2 model.Like interleukin 12 (IL-12),interleukin 35 (IL-35) which belongs to the IL-12 family can effectively enhance the function of the Tregs and inhibit the proliferation and differentiation of Thl7 cells,the excessive immune response,and immune damage to the body.It can be concluded that IL-35 could be involved and may play a protective role in the pathogenesis and regulation of asthma through a variety of pathways.This review introduces the biological characteristics of IL-35 and its role in the development and pathogenesis of asthma.关键词
白介素35/哮喘/调节性T细胞/辅助T细胞-17Key words
IL-35/asthma/Tregs/Th17分类
医药卫生引用本文复制引用
吕平,彭万胜,董淮富..新型抑制性细胞因子IL-35与支气管哮喘的研究进展[J].中国临床药理学与治疗学,2018,23(2):230-234,5.基金项目
安徽省自然科学基金青年项目(1608085QH188) （1608085QH188）
