中国免疫学杂志2018，Vol.34Issue(4)：602-608,7.DOI:10.3969/j.issn.1000-484X.2018.04.024
神经小胶质细胞在EAE脱髓鞘和髓鞘再生中的作用机制进展
Advances in mechanisms of microglial function on demyelination and remyelination in EAE model
摘要
Abstract
Inflammatory cells infiltration and demyelination in the central nervous system (CNS) are the main pathological characteristics of multiple sclerosis(MS),an autoimmune disease in the CNS.Most of the related pathological studies are carried out in the animal model experimental autoimmune encephalomyelitis(EAE).Microglia(MG) are the primary immune effector cells of the CNS and their activation can play complex roles in demyelination and remyelination during EAE.In detail,M1 phenotype is an important cause of demyelination and detrimental to remyelination while M2 phenotype can promote remyelination and inhibit demyelination.In this review,we not only focus on advances in the direct mechanisms of microglial function on demyelination and remyelination in EAE model,also the indirect mechanisms by astrocytes.关键词
神经小胶质细胞/实验性自身免疫性脑脊髓膜炎/多发性硬化/脱髓鞘/髓鞘再生Key words
Microglia/Experimental autoimmune encephalomyelitis/Multiple sclerosis/Demyelination/Remyelination分类
医药卫生引用本文复制引用
叶妮,李国陵,程晓东..神经小胶质细胞在EAE脱髓鞘和髓鞘再生中的作用机制进展[J].中国免疫学杂志,2018,34(4):602-608,7.基金项目
本文为国家自然科学基金面上项目(81173630、81673669、81703782)和上海中医药大学高峰学科建设项目(30304114323). （81173630、81673669、81703782）
