中国现代医学杂志2018，Vol.28Issue(11)：33-43,11.DOI:10.3969/j.issn.1005-8982.2018.011.007
MicroRNA基因单核苷酸多态性与类风湿关节炎的相关性研究
Relationship between single nucleotide polymorphisms of microRNA gene and rheumatoid arthritis
谢传美 1袁国华1
作者信息
- 1. 川北医学院附属医院 风湿科,四川 南充 637000
- 折叠
摘要
Abstract
Objective To identify the associations of single nucleotide polymorphism (SNP) loci rs2910164, rs3746444, rs2292832 and rs11614913 of miR-146a, miR-499a, miR-149 and miR-196a with rheumatoid arthritis (RA) in a Chinese Han population. Methods A case-control genetic association study was carried out in 600 patients with RA and 398 healthy individuals. The four SNPs were selected for genotyping by multiplex polymerase chain reaction and ligase detection reaction. Results The rs3746444 CT genotype was correlated with the activity and severity of RA in Chinese Han population. Moreover, gene-sex (rs11614913-sex) interaction was identified by GMDR analysis. However, we did not find any significant association of rs2910164, rs2292832 or rs11614913 with RA risk, severity, or activity. Conclusions The miR-499a polymorphism (rs3746444) is associated with the disease severity and activity of RA, which needs further replication and validation.关键词
类风湿关节炎/单核苷酸多态性/微小RNAKey words
rheumatoid arthritis/single nucleotide polymorphism/microRNAs分类
医药卫生引用本文复制引用
谢传美,袁国华..MicroRNA基因单核苷酸多态性与类风湿关节炎的相关性研究[J].中国现代医学杂志,2018,28(11):33-43,11.
