中国现代医学杂志2018，Vol.28Issue(11)：44-47,4.DOI:10.3969/j.issn.1005-8982.2018.011.008
VGLL4蛋白在胃癌和癌旁组织中的表达及其临床意义
Expression of VGLL4 protein in gastric carcinoma tissues and its relationships with clinicopathological parameters
韩新影 1刘红正 2孙杰 1张志刚1
作者信息
- 1. 河北省沧州市人民医院 病理科,河北 沧州 061000
- 2. 河北省沧州中西医结合医院,河北 沧州 061001
- 折叠
摘要
Abstract
Objective To investigate the expression of VGLL4 protein in gastric carcinoma tissues and its relationships with clinicopathological parameters. Methods The expressions of VGLL4 protein were determined with immunohistochemical SP method in 168 samples of gastric cancer and adjacent tissues. Their correlations with clinicopathological parameters were analyzed. Results The positive expression of VGLL4 protein mainly located in the nuclei, in a few incidence in the cytoplasm. VGLL4 protein expression was reduced in the gastric cancer tissues. The VGLL4 expression was less in the gastric cancers with deep infiltration, lymph node metastasis and high TNM stage, suggesting that low expression of VGLL4 protein in gastric cancer was associated with poor prognosis. Conclusions VGLL4 protein expression in gastric cancer is lower than that in the adjacent tissues and negatively correlated with tumor progression and tumor malignancy. VGLL4 is a potential tumor suppressor protein.关键词
胃癌/免疫组织化学法/VGLL4/临床病理特征Key words
gastric cancer/immunohistochemistry/VGLL4/clinicopathological parameters分类
医药卫生引用本文复制引用
韩新影,刘红正,孙杰,张志刚..VGLL4蛋白在胃癌和癌旁组织中的表达及其临床意义[J].中国现代医学杂志,2018,28(11):44-47,4.
