中国药房2017，Vol.28Issue(36)：5049-5052,4.DOI:10.6039/j.issn.1001-0408.2017.36.03
中药麻黄汤的分子药理学机制研究
Study on Molecular Pharmacology Mechanism of TCM Mahuang Decoction
摘要
Abstract
OBJECTIVE:To provide theoretical reference for clinical research and application of TCM Mahuang decoction.METHODS:TCM components of Mahuang decoction were analyzed by literature searching and data analysis,and TCM component database was established.The active compounds were selected through computer simulation prediction,and the related targets were predicted.Molecular pharmacology mechanism of TCM Mahuang decoction in the treatment of typhoid syndrome was investigated.RESULTS:Mahuang decoction contained about 723 compounds,among which E.sinica contained 236 compounds,Cinnamomum cassia contained 115 compounds,Glycyrrhiza uralensis contained 287 compounds,and Amygdalus Communis contained 85 compounds.43 active compounds were screened through computer simulation prediction,and 18 related targets were mainly related to vasodilation effect,adrenergic action and the effect of promoting smooth muscle contraction.CONCLUSIONS:By combining oral bioavailability prediction by computer,drug-like analysis and target prediction,the study determines the effect of active compounds in Mahuang decoction on typhoid syndrome by the means of vasodilation,adrenergic action and promoting smooth muscle contraction.关键词
中药/麻黄汤/分子药理学/机制研究Key words
TCM/Mahuang decoction/Molecular pharmacology/Mechanism study分类
医药卫生引用本文复制引用
马江..中药麻黄汤的分子药理学机制研究[J].中国药房,2017,28(36):5049-5052,4.基金项目
内蒙古自治区教育厅课题(No.NJSY11303) （No.NJSY11303）
