中国药房2017，Vol.28Issue(36)：5072-5075,4.DOI:10.6039/j.issn.1001-0408.2017.36.09
破伤风抗毒素致不良反应2636例文献分析
Literature Analysis of 2 636 Cases of Adverse Drug Reaction Induced by Tetanus Antitoxin
摘要
Abstract
OBJECTIVE:To investigate general regularity and characteristics of tetanus antitoxin (TAT) induced by ADRs,in order to provide reference for rational drug use in the clinic.METHODS:Domestic and foreign literatures on ADRs induced by TAT were retrieved,and related information of 2 636 case of ADR were analyzed statistically.RESULTS:Among patients whose gender and age were recorded,male with ADR induced by TAT was more than female,mainly aged 15-35 years old,accounting for 70.32 ％ (289/411);28.28 ％ (56/198) used water for injection;ADR occurred within 30 min after medication in 5.84％ (154/2 636)cases;main ADR were lesion of skin and its appendents,circulatory system damage,systemic reaction damage.Main clinical manifestations were urticaria,rash,chest tightness and anaphylaetic shock,etc.Ten cases died and 7 cases had sequelae;the rest were all recovered and cured after symptomatic treatment.CONCLUSIONS:TAT has a higher proportion of allergic reactions,especially anaphylactic shock,but great importance should be attached to rare auditory and vestibular dysfunction,visual impairment,elevated white blood cell count and other ADR.It is suggested to strengthen medication monitoring and used drugs strictly in accordance with drug package inserts so as to promote rational drug use.关键词
破伤风抗毒素/不良反应/文献分析/合理用药Key words
Tetanus antitoxin/ADR/Literature analysis/Rational drug use分类
医药卫生引用本文复制引用
余超,徐玉茗,徐瑾,万凯化,袁兴东,李穗,周鹃..破伤风抗毒素致不良反应2636例文献分析[J].中国药房,2017,28(36):5072-5075,4.基金项目
江西省自然科学基金资助项目(No.20142BAB205018) （No.20142BAB205018）
