中国药房2017，Vol.28Issue(36)：5106-5110,5.DOI:10.6039/j.issn.1001-0408.2017.36.18
桃红四物汤加减辅助治疗外伤性骨折临床疗效和安全性的系统评价
Clinical Efficacy of Modified Taohong Siwu Decoction in Adjuvant Therapy of Traumatic Fracture: A Systematic Review
摘要
Abstract
OBJECTIVE:To systematically review the therapeutic efficacy and safety of modified Taohong siwu decoction in adjuvant therapy of traumatic fracture,and to provide evidence-based reference in clinic.METHODS:Retrieved from CJFD,CBM,Wanfang database and PubMed,related studies about fracture restitution combined with modified Taohong siwu decoction (trial group) vs.fracture restitution alone (control group) in the treatment of traumatic fracture were collected.Meta-analysis was conducted by using Rev Man 5.3 statistical software after data extraction and quality evaluation according to Cochrane systematic review.RESULTS:A total of 6 RCTs and 3 clinical control trials were included,involving 929 patients.Meta-analysis showed that clinical total response rate [RR =1.35,95 ％ Cl (1.24,1.47),P ＜ 0.001] and the incidence of gastrointestinal ADR [RR =5.59,95 ％ Cl (1.30,24.14),P=0.02] in trial group were significantly higher than control group;symptom and sign score [MD =-5.50,95 ％ Cl(-6.45,-4.54),P＜0.001],erythrocyte sedimentation [MD=-13.78,95％ Cl(-15.97,-11.60),P＜0.01],whole blood viscosity [MD=-1.03,95％Cl(-1.11,-0.95),P＜0.001],plasma viscosity [MD=-0.24,95％Cl(-0.27,-0.21),P＜0.01],hematocrit [MD=-12.12,95％Cl(-13.37,-10.86),P＜0.01] and erythrocyte electrophoresis time [MD=-7.12,95％Cl(-7.88,-6.35),P＜ 0.01] of trial group were significantly lower than those of control group,with statistical significance.CONCLUSIONS:For adjunctive therapy of traumatic fracture,modified Taohong siwu decoction can improve clinical efficacy,reduce the inflammatory reaction, improve blood rheology but aggravate gastrointestinal reaction.关键词
桃红四物汤加减/骨折整复/外伤性骨折/Meta分析/疗效/安全性Key words
Modified Taohong siwu decoction/Fracture restitution/Traumatic fracture/Meta-analysis/Therapeutic efficacy/Safety分类
医药卫生引用本文复制引用
王晓彤,林海雄,肖志勋,黄冬欢,金远林,黄枫..桃红四物汤加减辅助治疗外伤性骨折临床疗效和安全性的系统评价[J].中国药房,2017,28(36):5106-5110,5.基金项目
全国名老中医药专家传承工作室建设项目(No.中医药人教发[2013]47号) （No.中医药人教发[2013]47号）
广州中医药大学大学生创新创业训练计划项目(No.201710572313) （No.201710572313）
