中国药房2017，Vol.28Issue(36)：5111-5115,5.DOI:10.6039/j.issn.1001-0408.2017.36.19
六味五灵片联合恩替卡韦治疗慢性乙型肝炎的Meta分析
Meta-analysis of Liuwei Wuling Tablets Combined with Entecavir in the Treatment of Chronic Hepatitis B
摘要
Abstract
OBJECTIVE:To evaluate the effectiveness of Liuwei wuling tablets combined with entecavir in the treatment of chronic hepatitis B (CHB),and to provide evidence-based reference in clinic.METHODS:Retrieved from Cochrane library,PubMed,Web of Science,CJFD,Wanfang database and VIP,randomized controlled trials (RCTs) about Liuwei wuling tablets combined with entecavir (trial group) vs.entecavir alone (control group) in the treatment of CHB were collected.Meta-analysis was conducted by using Rev Man 5.3 statistical software after data extraction and quality evaluation with Cochrane systematic evaluator manual 5.1.0.RESULTS:A total of 8 RCTs were included,involving 728 patients.Results of Meta-analysis showed that the levels of ALT [MD=-16.67,95 ％ CI (-19.83,-13.51),P＜ 0.001],AST [MD =-20.52,95％ CI (-25.65,-15.39),P＜0.001] and TBIL [MD=-5.85,95％CI(-11.31,-0.38),P=0.04] in trial group were significantly lower than control group;clinical total response rate [RR=1.23,95％CI(1.03,1.46),P=0.02] and HBeAg negative conversion rate [RR=1.26,95％CI(1.03,1.54),P=0.02] were significantly higher than control group,with statistical significance.There was no statistical significance in the rate of serum HBV DNA negative conversion [RR=1.22,95％ CI(0.99,1.52),P=0.07] between 2 groups.CONCLUSIONS:Compared with entecavir alone,Liuwei wuling tablets combined with entecavir in the treatment of CHB have better efficacy,can significantly improve the biochemical indexes of liver function in patients.关键词
六味五灵片/慢性乙型肝炎/Meta分析/疗效Key words
Liuwei wuling tablets/Chronic hepatitis B/Meta-analysis/Therapeutic efficacy分类
医药卫生引用本文复制引用
周永峰,刘红宇,房吉祥,董旖,乔潆,张蓉蓉,张萍..六味五灵片联合恩替卡韦治疗慢性乙型肝炎的Meta分析[J].中国药房,2017,28(36):5111-5115,5.基金项目
全军后勤科研计划面上项目(No.cws14j072) （No.cws14j072）
湖南省自然科学基金资助项目(No.2016JJ2097) （No.2016JJ2097）
