中国药房2017，Vol.28Issue(36)：5119-5122,4.DOI:10.6039/j.issn.1001-0408.2017.36.21
参苓白术散联合氨基水杨酸制剂治疗溃疡性结肠炎的Meta分析
Meta-analysis of Shenling Baizhu Powder Combined with Aminosalicylic Acid Preparation in the Treatment of Ulcerative Colitis
摘要
Abstract
OBJECTIVE:To evaluate clinical efficacy of Shenling baizhu powder combined with aminosalicylic acid in the treatment of ulcerative colitis (UC),and to provide evidence-based reference in clinic.METHODS:Retrieved from PubMed,Cochrane library,CJFD,VIP,Wanfang database and CBM,randomized controlled trials (RCTs) about Shenling baizhu powder combined with aminosalicylic acid preparations (trial group) vs.aminosalicylic acid preparations alone (control group) in the treatment of UC were collected.Meta-analysis was performed by using Rev Man 5.2 statistical software afder data extraction and quality evaluation with Cochrane systematic evaluator manual 5.1.0.RESULTS:A total of 14 RCTs were included,involving 1 177 patients.Meta-analysis showed that total response rate of trial group was significantly higher than that of control group [OR=3.40,95％ CI (2.44,4.74),P＜0.001],while Sutherland DAI score [MD=-1.31,95％ CI (-2.07,-0.56),P＜0.001],the levels of TNF-α [SMD=-1.90,95％CI(-2.90,-0.90),P＜0.001],IL-17[MD=-85.18,95％CI(-100.51,-69.85),P＜0.001] and IL-23 [MD=-113.27,95％CI(-132.34,-94.21),P＜0.001] in trial groups were significantly lower than control group,with statistical significance.CONCLUSIONS:Therapeutic efficacy of Shenling baizhu powder combined with aminosalicylic acid preparation is better than aminosalicylic acid preparation alone in the treatment of UC,and can significantly reduce Suthedand DAI and the levels of serum cytokines.关键词
参苓白术散/氨基水杨酸制剂/溃疡性结肠炎/随机对照试验/Meta分析/疗效Key words
Shenling baizhu powder/Aminosalicylic acid preparations/Ulcerative colitis/Randomized controlled trials/Meta-analysis/Therapeutic efficacy分类
医药卫生引用本文复制引用
吴科锐,罗景山,吴江凤,何天明,谭黎鑫,李先涛..参苓白术散联合氨基水杨酸制剂治疗溃疡性结肠炎的Meta分析[J].中国药房,2017,28(36):5119-5122,4.基金项目
广东省省级大学生创新创业训练项目(No.201610572070) （No.201610572070）
