中国药房2018，Vol.29Issue(1)：121-124,4.DOI:10.6039/j.issn.1001-0408.2018.01.30
安宫牛黄丸联合化学药治疗重型颅脑损伤及影响患者外周血Mg2+浓度的Meta分析
Meta-analysis of Angong Niuhuang Pill Combined with Chemical Drug in the Treatment of Severe Craniocerebral Injury and Its Effect on Patient's Mg2+ Concentration in Peripheral Blood
摘要
Abstract
OBJECTIVE:To evaluate clinical efficacy of Angong niuhuang pill combined with chemical drug in the treatment of severe craniocerebral injury and its effect on the concentration of Mg2+ in peripheral blood,and to provide evidence-based reference in clinic.METHODS:Retrieved from Chinese Journal Full-text Database,China Science and Technology Journal Database,China Bxdxiology Medicine disc,Wanfang Database,Chinese Clinical Trial Registry,PubMed,Excerpta Media Database,The Cochrane Library,Web of Science,Clinical Trials,and related literatures of intemet searched by Google Scholar,randomized controlled trials (RCT) about Angong niuhuang pill combined with chemical drug (trial group) vs.chemical drug (control group) in the treatment of severe craniocerebral injury and its effects on the concentration of Mg2+ in peripheral blood were collected.After literature screening,data extraction,quality evaluation with modified Jadad scale,meta-analysis of Glasgow Coma Scale (GCS) scores and Mg2+ concentration in peripheral blood were conducted by using Rev Man 5.3 statistical software after 7 d of treatment.RESULTS:A total of 6 RCTs were included,involving 773 patients.Results of meta-analysis showed that GCS [MD=2.87,95％CI (1.64,4.10),P＜0.01] and Mg2+ concentration in peripheral blood [MD=0.11,95％CI(0.06,0.16),P＜0.01] of trial group were significantly higher than those of control group,with statistical significance.CONCLUSIONS:Therapeutic efficacy of Angong niuhuang pill combined with chemical drug is better than that of chemical drug alone in the treatment of severe craniocerebral injury,can improve clinical symptom and prognosis.关键词
重型颅脑损伤/安宫牛黄丸/Meta分析/Mg2+浓度/化学药/格拉斯哥昏迷评分Key words
Severe craniocerebral injury/Angong niuhuang pill/Meta-analysis/Mg2+ concentration/Chemical drug/Glasgow Coma Scale分类
医药卫生引用本文复制引用
涂淮,彭皓均,赖纪才,庾国桢,杨小梅,吴智兵,曾征伦..安宫牛黄丸联合化学药治疗重型颅脑损伤及影响患者外周血Mg2+浓度的Meta分析[J].中国药房,2018,29(1):121-124,4.基金项目
广东省科技计划项目(No.2012B031800423) （No.2012B031800423）
