中国药理学通报2018，Vol.34Issue(4)：456-458,3.DOI:10.3969/j.issn.1001-1978.2018.04.004
线粒体损伤与糖尿病心肌病发病关系的研究进展
Research progress of mitochondria in diabetic cardiomyopathy
摘要
Abstract
Diabetic cardiomyopathy (DCM) is one of the major cardiovascular complications of diabetes mellitus. Currently, there is a lack of effective treatment for DCM,and its pathophys-iology is quite complex. Mitochondria are the main source of car-diomyocyte energy and play an important role in regulating ener-gy metabolism. Mitochondria are swollen and fragmented in dia-betic patients, leading to impaired mitochondrial function, sug-gesting that mitochondrial damage and dysfunction may play an important role in the pathogenesis of DCM. In this paper, the relationship between mitochondrial damage and the pathogenesis of DCM was reviewed from the aspects of abnormal mitochondrial energy metabolism,mitochondrial oxidative stress enhancement, mitochondrial kinetics,mitochondrial heart lecithin change,and mitochondrial calcium disorder.关键词
糖尿病心肌病/线粒体损伤/能量代谢异常/氧化应激/心磷脂/钙紊乱Key words
diabetic cardiomyopathy/mitochondrial injury/ab-normal energy metabolism/oxidative stress/cardiolipin/calci-um disorder分类
医药卫生引用本文复制引用
刘涛,李晶,鲍翠玉..线粒体损伤与糖尿病心肌病发病关系的研究进展[J].中国药理学通报,2018,34(4):456-458,3.基金项目
国家自然科学基金资助项目(No 51703055) （No 51703055）
湖北省自然科学基金资助项目(No 2017CFB699,2015CFC773) （No 2017CFB699,2015CFC773）
湖北省教育厅科学研究计划项目(No B201696) （No B201696）
湖北科技学院糖尿病专项基金(No 2016-18XZ09,14ZX-02) （No 2016-18XZ09,14ZX-02）
