中国药理学通报2018，Vol.34Issue(4)：463-466,4.DOI:10.3969/j.issn.1001-1978.2018.04.006
Cdk5介导的凋亡与自噬交互作用对脑缺血的调控
Regulation on intercross effect between Cdk5 mediated apoptosis and autophagy after cerebral ischemia
摘要
Abstract
Cyclin-dependent kinase 5 (Cdk5),as a key neuro-nal regulator,has received extensively attention. In our previous experiments, we have preliminary confirmed the importance of the regulation on neuronal apoptosis after cerebral ischemia by Cdk5 signal path. According to the documents reported, we found that there were signal transductions between apoptosis and autophagy, which acted the"rapier"position after cerebral is-chemia. Furthermore,Cdk5 could mediate protein kinase B(Akt or PKB) to play bidirectional regulation on the intercross be-tween apoptosis and autophagy. So,there would be of great sig-nificance to reveal the signal transduction relationship between apoptosis and autophagy mediated by Cdk5. Owing to the impor-tance of the intercross-effect between the two programmed cell death paths,we aimed at the imparity viewpoints between apop-tosis and autophagy after cerebral ischemia, raising the sugges-tions as follows:it is appropriate to reveal the effects of Cdk5 on Akt kinase dynamically, and discuss the double regulation mechanism of co-regulators between apoptosis and autophagy af-ter cerebral ischemia, which would provide references for the following researches.关键词
脑缺血/细胞周期素依赖性蛋白激酶5/蛋白激酶B/神经元凋亡/自噬/交互作用Key words
cerebral ischemia/cyclin-dependent kinase 5/PKB/neuronal apoptosis/autophagy/intercross effect分类
医药卫生引用本文复制引用
刘芳,周小江,陈乃宏..Cdk5介导的凋亡与自噬交互作用对脑缺血的调控[J].中国药理学通报,2018,34(4):463-466,4.基金项目
国家自然科学基金资助项目(No 81704064) （No 81704064）
湖南省科技厅重点研发项目(No 2017NK2261) （No 2017NK2261）
湖南省十二五中药学重点学科资助 （）
