中国药理学通报2018，Vol.34Issue(4)：467-472,6.DOI:10.3969/j.issn.1001-1978.2018.04.007
噻吩取代长链查尔酮对肿瘤侵袭的抑制作用
Tumor invasion inhibition of thiophene substituted long chain chalcones
摘要
Abstract
Aim To elucidate the structure-activity re-lationship between a new class of long chain chalcone compounds and tumor invasion. Methods The basic idea of the research was to enhance the specificity by prolonging the molecular structure. Based on the lead compound TSAHC, the thiophene was used as the main derivative at the carbonyl groups to obtain six new chalcones. Then we evaluated the anti-tumor activities of the compounds and the expression of key protein MMP-2 of the tumor invasion. Finally, six new com-pounds were docked to the protein by the SYBYL soft-ware. Results The structures of the six compounds were confirmed by H-NMR and MS. Among them, compound 2,3 showed fine capability to inhibit tumor invasion. The docking results also showed that the sul-fonamide and thiophene groups of the compounds had positive contribution to the target binding of the com-pounds. Conclusion Cell experiments and molecular docking show that the long chain modification of chal-cone by using thiophene as a derivative group can sig-nificantly enhance the anti-tumor invasion.关键词
查尔酮/肿瘤侵袭/MMP-2/分子对接/构效关系/噻吩Key words
chalcone/tumor invasion/MMP-2/mo-lecular docking/QSAR/thiophene分类
医药卫生引用本文复制引用
赵松峰,张珩,魏涵,刘芝梅,张晓坚,刘子维..噻吩取代长链查尔酮对肿瘤侵袭的抑制作用[J].中国药理学通报,2018,34(4):467-472,6.基金项目
国家自然科学基金资助项目(No 31700291) （No 31700291）
湖北省自然科学基金面上项目(No 2017CFB712) （No 2017CFB712）
郑州大学第一附属医院院内创新青年基金项目(No ZDYQNNJJ-2015) （No ZDYQNNJJ-2015）
武汉工程大学青年人才项目(No 237114) （No 237114）
