摘要
Abstract
Objective The peripheral motor nerve conduction velocity (MCV) and sensory nerve conduction velocity (SCV) in patients with type 2 diabetes mellitus (T2DM) were measured, and the stages of diabetic retinopathy (DR) were analyzed. The relationship between peripheral nerve conduction velocity and DR in T2DM was analyzed. Method From January 2016 to January 2017, 100 patients with T2DM for more than 5 years who were diagnosed in the department of endocrinology of the First People's Hospital of Jinzhong were studied. The MCV and SCV of the ulnar nerve, median nerve, tibial nerve, peroneal nerve, gastrocnemius nerve and superficial peroneal nerve were detected in the patients, fundus fluorescein angiography was performed and the levels of glycated hemoglobin A1c (HbA1c), serum uric acid, blood lipid and homocysteine (Hcy) were measured. Analyzed the characteristics of peripheral nerve injury in patients with T2DM, and compared the prevalence of DR in nerve conduction slow down group and normal group, and the prevalence of nerve conduction slows in DR patients. Further analyzed the common risk factors of diabetic peripheral neuropathy (DPN) and DR. Result Among the 100 patints, patients with DR accounted for 78% (78/100), and slow nerve conduction patients accounted for 76% (76/100). In the nerve conduction slow down group, the anomalous rate of median nerve SCV was 60.53% (46/76), the anomalous rate of nervi peronaeus superficialis SCV was 42.11% (32/76), the anomalous rate of nervi cutaneus surae medialis SCV was 36.84% (28/76), the anomalous rate of nervi tibialis MCV was 27.63% (21/76). Nerve conduction in DR patients was 79.5%. The prevalence of DR in nerve conduction slow down group was 92.1%, and the prevalence of DR in normal group was 33.3%. There was a significant difference in the prevalence of DR between two groups (P<0.05). There was no significant difference between the injured nerves and the prevalence of DR. HbA1c, Hcy and low density lipoprotein cholesterol were the risk factors for DPN in T2DM patients. HbA1cand Hcy were the risk factors for DR in patients with T2DM, HbA1cand Hcy were the common risk factors for DR and DPN. Conclusion Patients with T2DM combined with DPN have more sensory nerve injuries than motor nerves, legs nerve damage more than upper limb. DR is earlier than DPN in patients with T2DM with a course of more than 5 years. Clinically, we can detect DPN by noninvasive examination of nerve conduction velocity, and we can assess the prevalence of diabetic retinopathy.关键词
2型糖尿病/糖尿病周围神经病变/糖尿病视网膜病变/神经传导速度Key words
Type 2 diabetes mellitus/Diabetic peripheral neuropathy/Diabetic retinopathy/Nerve conduction velocity
