中国真菌学杂志2018，Vol.13Issue(1)：11-14,4.
血浆1,3-β-D葡聚糖检测联合念珠菌评分对侵袭性真菌感染的诊断价值
Diagnostic value of plasma 1,3-β-D-glucan combined with Candida score in patients with invasive fungal infections
摘要
Abstract
Objective To discuss the diagnostic value of plasma 1,3-β-D-glucan (G test) and Candida score (CS) to invasive fungal infection (IFI).Method Collecting clinical information of 201 patients with high risk of invasive Candida infection treated in the ICU of someone hospital from June 2011 to June 2016,according to diagnostic criteria of European cancer research and treatment group and fungal research group (EORTC/MSG),9 cases as proven were diagnosed as proven,73 cases as probable,29 cases as possible,90 cases as non-invasive infection.Microbiology Kinetic Rapid Reader MB-80 was used to measure the concentration of plasma 1,3-β-D-glucan (exceed 10pg/mL is regarded as positive),and Candida score was utilized in those patients (exceed 3 scores is regarded as positive),then to calculate the sensitivity,specificity,positive predictive value,negative predictive values for G test and Candida score used exclusively or jointly.Result Respiratory tract was the most probable infected site,and Candida albicans was the main pathogenic fungi.In all patients 88 cases was positive by G test,85 cases is positive by Candida score.Plasma 1,3-β-D-glucan and Candida score were used jointly,whose sensitivity,specificity,positive predictive value,and negative predictive values were 95.1％,71.1 ％,75.0 ％,94.1 ％;compared with plasma 1,3-β-D-glucan and Candida score used exclusively,whose sensitivity and negative predictive value were the highest,specificity and positive predictive value were approximate among them.Conclusion When plasma 1,3-[β-D-glucan and Candida score were used jointly,sensitivity and negative predictive value were higher than that were used alone,plasma 1,3-β-D-glucan combined with Candida score had more significant diagnostic value.关键词
1,3-β-D葡聚糖/念珠菌评分/侵袭性真菌感染/诊断Key words
1,3-β-D-glucan/Candida score/invasive fungal infection/diagnosis分类
医药卫生引用本文复制引用
徐明均,张慧婷,张玉洁,徐玉洁,孙小鹏,马晓薇..血浆1,3-β-D葡聚糖检测联合念珠菌评分对侵袭性真菌感染的诊断价值[J].中国真菌学杂志,2018,13(1):11-14,4.基金项目
宁夏医科大学2014年校级科研项目(XT201418),宁夏医科大学临床医学一流学科建设项目(YXW2017014),宁夏回族自治区科技支撑计划项目 （XT201418）
