中国真菌学杂志2018，Vol.13Issue(1)：20-23,4.
重症患者念珠菌菌种分布及卡泊芬净敏感性分析
Distribution and in vitro antifungal susceptibilities to caspofungin of Candida species isolated from critical ill patients
摘要
Abstract
Objective To investigate the distribution and in vitro activity of isolates of Candida from critical ill patients of general intensive care unit (ICU),aiming to guide the selection of antifungal.Methods All Candida isolates were taken from adult critical ill patients of general ICU from Sun Yat-sen Memorial Hospital,Sun Yat-sen University,with ICU stay more than 3 days during February 2015 between February 2016 were identified and then tested for susceptibility to caspofungin using the CLSI M27-A3 broth microdilution method.Results 76 isolates of Candida were collected.37 isolates of Candida spp,accounted for 48.7％,20 isolates of C.tropicalis (26.3％),8 isolates of C.glabrata and 8 isolates of C.parapsilosis (10.5％).1 isolates of C.krusei,C.guilliermondii and C.lusitaniae each.Candida spp.remains high susceptibility to caspofungin (94.7 ％) in general ICU from Sun Yat-sen Memorial Hospital,Sun Yat-sen University.Resistance was found in 1 C.glabrata isolate,intermediate were found in 2 C.glabrata isolates and 1 C.albicans isolate.Conclusions C.albicans was the most commonly species among critical ill patients of general ICU from Sun Yat-sen Memorial Hospital,Sun Yat-sen University.The most frequently identified species of non-C.albicans is C.tropicalis.Most Candida spp.isolates remain high susceptibility to caspofungin in critical ill patients.关键词
重症患者/卡泊芬净/侵袭性真菌病/耐药性分析Key words
critically ill patient/caspofungin/invasive fungal disease/resistance of fungi分类
医药卫生引用本文复制引用
李方义,张静,邹子俊,易修文,李伟超,周林,郑煜凯,何志捷..重症患者念珠菌菌种分布及卡泊芬净敏感性分析[J].中国真菌学杂志,2018,13(1):20-23,4.基金项目
中华医学会临床医学科研专项资金(1430310568) （1430310568）
广东省部产学研项目(2012B091100456) （2012B091100456）
