中华骨质疏松和骨矿盐疾病杂志2017，Vol.10Issue(6)：524-529,6.DOI:10.3969/j.issn.1674-2591.2017.06.005
2型糖尿病患者血清羧化不全骨钙素与糖、脂代谢的相关性
Relationship between serum undercarboxylated osteocalcin and glucose and lipid metabolism in type 2 diabetes
康京京 1梅涛 2王炜 1祝捷 1吴玉洁 1陈超 1邢学农1
作者信息
- 1. 230001合肥,安徽医科大学附属安徽省立医院内分泌科
- 2. 230001合肥,安徽医科大学附属安徽省立医院体检中心
- 折叠
摘要
Abstract
Objective To explore the relationship between serum undercarboxylated osteocalcin (ucOC) and glucose and lipid metabolism in type 2 diabetes.Methods A total of 123 patients with type 2 diabetes were divided into three groups,including D1 group (less than 5 years group,43 cases),D2 group (5-15 years group,51cases) and D3 group (more than 15 years group,29 cases) according to the course,40 subjects with normal glucose tolerance were included as control group.Moreover,diabetic patients were divided into two groups according to the ucOC concentration.The associations of ucOC and serum glucose level as well as lipid metabolic indexes were examined.Results (1) Compared with control group,serum ucOC level was significandy reduced in diabetic group [(0.43±0.35) mg/L vs.(1.52±0.88) mg/L].But the serum triglyceride (TG) level in diabetic group was higher than that in the control group [(2.24±1.64) mmol/L vs.(1.44±0.76) mmol/L].(2) For diabetic patients,serum ucOC level was negatively correlated to glycosylated hemoglobin (HbAlc) and TG (P=0.005,P=0.008).And HbAlc was negatively correlated to serum fasting c-peptide (FCP) (P=0.009),and positively correlated to β-C-terminal telopeptide of type 1 collagen (CTX) (P =0.016).Conclusion Serum ucOC could regulate glucose and lipid metabolism,and may pariticipate in the onset of type 2 diabetes.关键词
2型糖尿病/骨钙素/羧化不全骨钙素/糖脂代谢Key words
type 2 diabetes mellitus/osteocalcin/undercarboxylated osteocalcin/glucose and lipid metabolism分类
医药卫生引用本文复制引用
康京京,梅涛,王炜,祝捷,吴玉洁,陈超,邢学农..2型糖尿病患者血清羧化不全骨钙素与糖、脂代谢的相关性[J].中华骨质疏松和骨矿盐疾病杂志,2017,10(6):524-529,6.
