摘要
Abstract
Objective To investigate the effects of montelukast sodium combined with pidot-imer on pulmonary function and immune function in children with recurrent respiratory tract infec-tions (RRTI). Methods Subjects were selected from January 2015 to January 2016 in outpatient clinic of Navy General Hospital for 78 patients with RRTI. According to the type of treatment of chil-dren were divided into control group and observation group,39 cases in each group. Two groups of patients were given pimodomu,atomization treatment and active anti-infection in general convention-al treatment,the observation group was added oral montelukast sodium treatment for three months. After the end of treatment, the two groups of patients with total effective rate, clinical symptoms, lung function and immune function were compared. Results The effective rate(94.87%) was sig-nificantly higher in the observation group than that in the control group (61.54%),and the differ-ence was statistically significant (P<0.05). The disappeared time of cough, fever and lung rales were shorter in the observation group than those in the control group,but the difference were not sta-tistically significant (P>0.05);the levels of forced vital capacity (FVC),forced expiratory volume in one second (FEV1), FEV1/FVC, 50% peak expiratory flow and peak expiratory flow in the two groups were significantly higher than those before treatment (P<0.05),and the observation group was significantly higher than in the control group (P<0.05); the levels of serum immunoglobulin (Ig)G, lgA,IgM,CD3+,CD4+and CD4+/CD8+in the two groups were significantly higher than those before treatment (P<0.05).Conclusion On the basis of general conventional treatment,montelukast sodi-um combined with pidotimer in children with RRTI has a higher efficiency and symptoms relieved, the symptoms improved more clearly,which is worth in clinical application.关键词
反复呼吸道感染/孟鲁司特钠/匹多莫德/肺功能/免疫功能/儿童Key words
Repeated respiratory tract infections(RRTI)/Montelukast sodium/Piedmont/Lung function/Immune function/Children分类
医药卫生
