转化医学杂志2018，Vol.7Issue(2)：86-89,4.DOI:10.3969/j.issn.2095-3097.2018.02.006
骨髓增生异常综合征患者肺功能的临床研究
Clinical research of pulmonary function in patients with myelodysplastic syndrome
摘要
Abstract
Objective To explore the pulmonary function of patients with myelodysplastic syndrome (MDS) and analyze it after hematopoietic stem cells transplantation(HSCT). Methods Fifty patients with MDS were experiment group chosen from January 2013 to October 2017 in Navy General Hospital,and 50 healthy cases were control group during the same period. All spirometric values were recorded including percentage predicted forced vital capacity (FVC),forced expiratory volume in one second(FEV1),vital capacity(VC),residual volume(RV),peak expiratory flow (PEF),maximal mid-expiratory flow (MMEF), and diffusing capacity of the lung for carbon mon-oxide (DLCO). To compare the lung function before and after HSCT during 6-12 months of 15 MDS patients who had accepted HSCT therapy.Results Patients in experimental group experienced a significant decrease in the predict percent of FVC,FEV1,VC,PEF,MMEF,DLCO,which were significantly different compared with those in control group (P<0.05). The predict percent of RV was increased,but no statistic difference. There were negative relationship between lung function, duration of diseases,lung infection frequency, and combined chemotherapy. After HSCT, the spi-rometric of MDS patients such as the predict percent of FVC, FEV1, VC, PEF, MMEF, DLCO were significantly decreased (P<0.01), compared with before transplantation. Conclusion The ventilatory function, small airway function and diffusion function of patients with MDS were dam-aged. Indices of lung function had negative relation with diseases duration,lung infection frequency, and combined chemotherapy. After HSCT,damages of above indices were aggravated.关键词
骨髓增生异常综合征/肺功能/造血干细胞移植Key words
Myelodysplastic syndrome (MDS)/Pulmonary function/Hematopoietic stem cell transplantation (HSCT)分类
医药卫生引用本文复制引用
李虎明,钱李仁,赖莉芬,舒六一,刘方,张春阳,韩志海..骨髓增生异常综合征患者肺功能的临床研究[J].转化医学杂志,2018,7(2):86-89,4.基金项目
国家重点实验室开放课题(NKMI2019K01) （NKMI2019K01）
军队后勤科研计划重点项目(BHJ16J011) （BHJ16J011）
