转化医学杂志2018，Vol.7Issue(2)：101-108,8.DOI:10.3969/j.issn.2095-3097.2018.02.010
用血清和呼气样品的拉曼指纹谱方法筛查早期肺癌与乳腺癌
The serum and breath Raman fingerprinting method for early lung cancer and breast cancer screening
摘要
Abstract
Each year in China there are about 3.10 million new cancer cases and about 2.00 million deaths. The early screening methods to address the risk of lung cancer, breast cancer and other malignant tumors have not yet been well developed. The implementation of the strategy to over-come the cancer "early detection, early diagnosis, early treatment" was unsatisfactory, as there is not currently an early cancer screening method that is non-invasive, cheap, convenient and effec-tive. Our pre-liminary research using the serum Raman fingerprint method to screen for lung cancer and early stage breast disease compared with healthy controls,with 10 specific spectral lines demon-strated that for united principal component analysis, the (+)accuracy rate was 100%, 86%, and 91.4%;the (-) false rate was 0, 14%, 8.6%; and for united hierarchical cluster analysis the (+) accuracy rate was 81.4%,86%,and 100%, the (-) false rate was 18.6%,14%, and 0%for lung cancer,early stage breast disease,and healthy controls,respectively. We suggest that ideal usage of Raman screening for early lung cancer include:(1) the sampling of both serum and breath to further enhance the high sensitivity and specificity of the Raman fingerprinting screening method for early stage cancers. Including both serum and breath will contains all the information from small molecules that are soluble in serum or in breath produced during the process of carcinogenesis in all cells of the patient;(2) a large sample database of stageⅠlung cancer cases to establish the early stage lung cancer metabolism characteristics Raman fingerprint database,and then,expand and cre-ate databases of breast,stomach,and other cancers at early stages;and(3) an increase in the na-tional systems engineering approach to popularizing research for early cancer screening, including hardware,software,and management.关键词
拉曼指纹谱/血清/呼气/肺癌/癌症筛查方法/主成份分析法/聚类分析法Key words
Raman fingerprinting/Serum/Breath/Lung cancer/Cancer screening method/principal component analysis (PCA)/hierarchical cluster analysis (HCA)分类
医药卫生引用本文复制引用
吴世法..用血清和呼气样品的拉曼指纹谱方法筛查早期肺癌与乳腺癌[J].转化医学杂志,2018,7(2):101-108,8.基金项目
国家自然科学基金项目(11074029) （11074029）
