浙江医学2018，Vol.40Issue(3)：252-254,3.DOI:10.12056/j.issn.1006-2785.2017.40.3.2017-1576
人巨细胞病毒UL133基因型在婴幼儿肝功能损伤中的分子机制
Mechanisms of UL133 gene-induced liver function impairment in infants with HCMV infection
摘要
Abstract
Objective To investigate the mechanisms of UL133 gene-induced liver function impairment ininfants with human cytomegalovirus (HCMV) infection.Methods Sixty-eight infants with HCMV hepatitis admitted in the Second Affiliated Hospital of Wenzhou Medical University and 66 healthy infants infected with HCMV were enrolled in the study.The HCMV UL133 gene expression in the urine was detected by RT-PCR and plasma levels of Caspase-3 and Caspase-6 were measured by ELISA.Results The positive rates of UL133 gene expression in infants with hepatits and healthy infants were 94.1％and 3.0％,respectively (P＜0.05).The plasma levels of ALT,Caspase-3 and Caspase-6 in positive group were significantly higher than those in negative group (P＜0.05),while there were no significant differences in TBiL,DBiL,GGT and AST levels between two groups (P＞0.05).Conclusion The UL133 genotype is associated with liver function injury,which may be mediated by up-regulation of Caspase-3 and Caspase-6 in infants with HCMV infection.关键词
人巨细胞病毒/UL133/肝炎/基因Key words
HCMV/UL133/Hepatitis/Gene引用本文复制引用
温正旺,陈敏,陈洁,石海矾,蔡晓红,陈益平..人巨细胞病毒UL133基因型在婴幼儿肝功能损伤中的分子机制[J].浙江医学,2018,40(3):252-254,3.基金项目
温州市科技计划项目(Y20160018) （Y20160018）
