浙江医学2018，Vol.40Issue(4)：320-324,5.DOI:10.12056/j.issn.1006-2785.2017.40.4.2016-2028
缺氧诱导因子-1α预测新辅助放化疗直肠癌患者病理完全缓解及预后的价值
Value of hypoxia-inducible factor-1α for predicting pathological complete response and survival in rectal cancer patients receiving neoadjuvant chemoradiotherapy
摘要
Abstract
Objective To assess the value of hypoxia-inducible factor 1α (HIF-1α) for predicting pathological response and clinical outcomes in rectal cancer patients treated with neoadjuvant chemoradiotheray (nCRT).Methods One hundred and fourteen patients with rectal cancer receiving nCRT before surgery from January 2010 to December 2015 were enrolled in the study.The expression of HIF-1α in tumor tissue was examined with immunohistochemistry.The predictive factors of pathological complete response (pCR),3-year recurrence-free survival and 3-year overall survival were analyzed.Results The high expression of HIF-1α was detected in 60 cases (52.6％).The expression of HIF-1α was correlated with tumor diameter before treatment and pCR(P＜0.05),not correlated to gender,age,BMI,distance from tumor to anus,T stage and N stage(all P ＞0.05).Multivariate logistic regression analysis showed that HIF-1α expression was correlated with pCR (P＜0.05).HIF-1α expression and ypTNM staging were correlated with 3-year recurrence free survival rate and 3-year overall survival rate (P＜0.05).Cox proportional risk regression model showed that the expression of HIF-1α was an independent predictor for recurrence free survival and overall survival (all P＜0.05).Conclusion HIF-1α can predict the efficacy of nCRT,and the prognosis of patients with rectal cancer.关键词
缺氧诱导因子-1α/直肠癌/新辅助放化疗/病理完全缓解/生存Key words
Hypoxia-inducible factor-1α/Rectal cancer/Neoadjuvant chemoradiotherapy/Pathologic complete response/Survival引用本文复制引用
蔡成,王建平,钟志凤,戴志慧,王庆华,董武真,施红旗,刘庆伟,杜金林..缺氧诱导因子-1α预测新辅助放化疗直肠癌患者病理完全缓解及预后的价值[J].浙江医学,2018,40(4):320-324,5.基金项目
金华市科学技术研究计划项目(2014-3-010) （2014-3-010）
