浙江医学2018，Vol.40Issue(4)：329-332,4.DOI:10.12056/j.issn.1006-2785.2017.40.4.2017-2377
高龄男性血清Ⅰ型原胶原氨基端前肽水平变化的独立相关因素研究
Independent factors associated with serum N-terminal propeptide of type 1 procollagen in men of advanced age
摘要
Abstract
Objective To probe into independent factors associated with serum N-terminal propeptide of type 1 procollagen (P1NP) in men of advanced age.Methods A cross-sectional survey was conducted in a cohort comprising 495 men aged ≥80 years.All subjects underwent a survey on underlying chronic diseases and lifestyle.The serum levels of bone metabolism markers(P1NP),parathyroid hormone(PTH),25-hydroxyvitamin D(25-OH-VD),biomedical index,anemia-related index as well as sex steroids were detected.Univariate analysis and multivariate regression analysis were performed to analyze the independent factors associated with P1NP.Results The univariate analyses demonstrated that P1NP was significantly related to type 2 diabetes mellitus,sun exposure,exercise,milk consumption,PTH,25-OH-VD,albumin,creatinine,calcium,phosphate,iron,folic acid,ferritin levels (all P＜0.05).The multivariate regression analysis revealed that exercise,and PTH,calcium,phosphate,creatinine levels were independent correlative factors with P1NP levels in men aged 80 and over(all P＜ 0.05).Conclusion To decrease the serum concentrations of parathyroid hormone and creatinine,and healthy lifestyle may be beneficial for serum P1NP level in men of advanced age.关键词
Ⅰ型原胶原氨基端前肽/甲状旁腺素/高龄/男性Key words
N-terminal propeptide of type 1 procollagen/Parathyroid hormone/Aged 80 and over/Men引用本文复制引用
杨其刚,边平达,李秀央,陈锦平..高龄男性血清Ⅰ型原胶原氨基端前肽水平变化的独立相关因素研究[J].浙江医学,2018,40(4):329-332,4.基金项目
浙江省医药卫生平台重点资助计划项目(2016ZDA002) （2016ZDA002）
