中医药学报2017，Vol.45Issue(6)：85-87,3.
星点设计-效应面法优选穿山龙咀嚼片提取工艺
Optimal Extraction Process of Dioscorea nipponica Makino Tablets by Central Composite Design Response Surface Method
摘要
Abstract
Objective:To optimize the extraction process of Dioscorea nipponica Makino tablets by central composite design response surface method(ccd-rsm).Methods:Ethanol concentration,extraction time,solvent ratio were taken as independent variables with diosgenin content as dependent variable,through multiple linear regression and binomial fitting each level of independent variables,using the response surface method to select out the best technology,and carried on the forecast analysis.Results:The optimum extraction process was 8 times of 80％ ethanol,twice extraction,each time for 120min,and the average deviation between the predicted and theoretical values was 1.4％,and the binomial fitting complex correlation coefficient was 0.976 9.Conclusion:Method of ccd-rsm was used to optimize the extraction process of Dioscorea nipponica Makino tablets,the method has the characteristic of easiness,high precision,and good predictability.关键词
穿山龙咀嚼片/星点设计/提取工艺Key words
Dioscorea nipponica Makino tablets/Central composite design/Extraction process分类
医药卫生引用本文复制引用
方芳,宋小雪,顾媛媛,郭玉岩,姚丽琴,田明,高士平,贾永囡,郑文韬..星点设计-效应面法优选穿山龙咀嚼片提取工艺[J].中医药学报,2017,45(6):85-87,3.基金项目
哈尔滨市科学技术局科技创新人才应用技术研究与开发(青年后备人才)项目(No.2016RQQXJ125) （青年后备人才）
黑龙江省博士后资助课题(No.LBH-Z16193) （No.LBH-Z16193）
