中医药学报2018，Vol.46Issue(2)：70-73,4.DOI:10.19664/j.cnki.1002-2392.180053
紫杉醇联合复方苦参注射液同步放化疗对食管癌老年患者的近期疗效及毒副作用
Concurrent Chemoradiotherapy of Paclitaxel Combined with Compound Kushen Injection Treating Elderly Patients with Esophagus Cancer:Analysis of Short-term Efficacy and Toxic and Side Effects
摘要
Abstract
Objective:To analyze the short -term efficacy and toxic and side effects of concurrent chemoradiotherapy of Paclitaxel(PTX)combined with compound Kushen injection treating elderly patients with esophagus cancer.Methods:118 elderly patients with esophagus cancer were randomly divided into the observation group(n=59)and the control group(n=59).The control group was treated with concurrent chemoradiotherapy of PTX;on which basis,the observa-tion group was also treated with compound Kushen injection to the end of chemoradiotherapy.The chemoradiotherapy was three months,and the follow-up was one year.The short -term clinical efficacy was compared between the two groups;immune function changes before and after the treatment,as well as the toxic and side effects during the follow -up were observed.Results:After three-month treatment,DCR was 96.61%in the observation group,which was sig-nificantly higher than 67.80%in the control group(P<0.05);during the follow-up,the survival rate was 86.44%in the observation group,which was also significantly higher than 67.80% in the control group(P<0.05).The blood CD+4ratio and CD +4/CD+8were significantly higher after the treatment than those before the treatment in the theatment group;they were much higher in the observation group compared to those in the control group(P<0.01); the blood CD+8ratio after the treatment in the observation group was significantly lower than that before the treatment and that in the control group(P<0.01).The serum levels of IgG,IgA and IgM were significantly lower in the control group after the treatment than those before the treatment and those in the observation group(P<0.01).During the treatment and follow-up period,the toxic and side effects,such as the incidence rates of grade I ~II appetite,vomiting,white blood cell descent, radiation esophagitis and grade III ~IV vomiting, were remarkably lower in the observation group than those in the control group(P<0.05).Conclusion: Concurrent chemoradiotherapy of PTX combined with compound Kushen injection can effectively control the progress of esophagus cancer in elderly patients, reduce the toxic and side effects,and increase the tolerance and improve survival rate.关键词
食管癌/紫杉醇/同步放化疗/复方苦参注射液/疗效/毒副反应Key words
Esophagus cancer/Paclitaxel/Concurrent chemoradiotherapy/Compound Kushen injection/Effect/Toxic and side effects分类
医药卫生引用本文复制引用
韩黎丽,陈小兵,吕慧芳,王丹,王茂勋,罗素霞..紫杉醇联合复方苦参注射液同步放化疗对食管癌老年患者的近期疗效及毒副作用[J].中医药学报,2018,46(2):70-73,4.基金项目
国家自然科学基金面上项目(81472714) （81472714）
