中医药学报2018，Vol.46Issue(2)：90-93,4.DOI:10.19664/j.cnki.1002-2392.180058
身痛逐瘀汤对痰瘀互结型膝骨关节炎患者血清IL-1β的调节作用
Regulating Effect of Shentong Zhuyu Decoction on Serum IL-1βand Its Influence on Hemorheology in Patients with Knee Osteoarthritis of Phlegm-stasis Pattern
摘要
Abstract
Objective:To observe the influence of Shentong Zhuyu decoction on serum level of IL -1βin the treatment of knee osteoarthritis of phlegm -stasis pattern,to discuss its action mechanism,and to verify its clinical curative effect. Methods:60 cases of knee osteoarthritis were randomly divided into the control group and the observation group; the control group was treated with Diclofenac Sodium combined with Diacerein, whereas the observation group was treated with Shentong Zhuyu Decoction;the treatment was two courses of eight weeks.IL-1βlevel,WOMAC joint index,he-morheology,clinical efficacy and safety analysis were compared in the two groups before and after the treatment.Re-sults:IL-1βlevel was significantly lowered in the synovial fluid and in serum after the treatment in the two groups(P<0.05),of which there was statistical difference between the observation group and the control group(P<0.05).In terms of indexes of hemorheology, they decreased more obviously in the observation group after the treatment(P <0.05).Scores of WOMAC were reduced more significantly in the observation group when compared to the control group (P<0.05).The total effective rate was 76.7%in the control group,and it was 90.0%in the observation group,there was statistical significance between the two groups(P<0.05).Adverse reactions were less in the observation group compared to those in the control group(P<0.05).Conclusion:Shentong Zhuyu decoction is effective in the treatment of knee osteoarthritis with phlegm -stasis syndrome, and its mechanism may be related to regulating the level of IL -1β,which provides reference for clinical medication.关键词
身痛逐瘀汤/IL-lβ/膝骨关节炎Key words
Shentong Zhuyu Decoction/IL-lβ/Osteoarthritis分类
医药卫生引用本文复制引用
李继超,赵娟,张延杰,黄霄汉..身痛逐瘀汤对痰瘀互结型膝骨关节炎患者血清IL-1β的调节作用[J].中医药学报,2018,46(2):90-93,4.基金项目
2015河南省中医药科学研究专项(2015ZY02008) （2015ZY02008）
