中医药学报2018，Vol.46Issue(2)：98-101,4.DOI:10.19664/j.cnki.1002-2392.180060
芪明颗粒对早期糖尿病肾病患者血清Cys-C和β2-MG水平的影响
Effects of Qiming Granule on Serum Levels of Cys-C and β2-MG in Patients with Early DN
摘要
Abstract
Objective:To observe the effect of Qiming granule on serum Cystatin C(Cys-C)and beta 2-microglobulin (β2-MG)in patients with early diabetic nephropathy(DN), and to explore its action mechanism when treating early DN.Methods:110 patients with early DN were randomly divided into the treatment group(n=55)and the control group (n=55).The both groups were given routine treatment and care;on which basis,the treatment group was also treated with Qiming Granule(1 bag/time,3 times/day),whereas the control group was given Valsartan Capsule(80mg/time,1 time/day).Serum levels of Cys-C and β2-MG,TCM symptoms were observed in the two groups to assess the clinical efficacy.Results:The total clinical efficacy was respectively 92.73%and 76.36%in the treatment group and the con-trol group,of which there was a significant difference(P<0.05).Serum levels of Cys -C and β2-MG were both im-proved after the treatment in the two groups,of which there was a statistical significance between the groups(P<0.05);however,there was no significant difference between prior treatment and post treatment in the control group(P>0.05). Conclusion:Qiming Granule was superior to Valsartan Capsule in improving TCM symptoms of early DN,it can signifi-cantly increase the serum levels of Cys -C and β2-MG,it can delay the development of DN.Qiming Granule is safe and effective in the treatment of early DN,which provides reference for the clinical application of Qiming Granule.关键词
芪明颗粒/糖尿病肾病/血清胱抑素C/β2微球蛋白Key words
Qiming Granule/Diabetic nephropathy/Serum Cys-C/β2-MG分类
医药卫生引用本文复制引用
王军媛,赵建红,刘颖,张军,李振,臧乐红,王玉红..芪明颗粒对早期糖尿病肾病患者血清Cys-C和β2-MG水平的影响[J].中医药学报,2018,46(2):98-101,4.基金项目
2014年度河北省中医药管理局科学技术课题(2014101) （2014101）
