安徽农业大学学报2018，Vol.45Issue(1)：45-49,5.DOI:10.13610/j.cnki.1672-352x.20180302.020
CD-1小鼠海马H3K9三甲基化水平的年龄化改变及其与认知功能改变的相关性研究
Changes of age-related H3K9 trimethylation in hippocampus and its correlation with cognitive impairment in CD-1 mice
摘要
Abstract
In this study,we explored the effect of age on trimethylation of histone 3 in the lysine 9 site (H3K9me3) and its correlation with the impairment of spatial learning and memory in CD-1 mice.The results showed that the number of errors and latency during learning and memory phases in the radial arm water maze (RAWM) in the mice aged at 18-and 12-month old was significantly longer or more than those in the 6-month old mice (Ps ＜0.05),with more number of errors in the learning and memory phases in the 18-month old mice compared to the 12-month old mice (Ps ＜0.05).A significantly higher level of H3K9me3 in the hippocampal DG and CA1 subregions was found in the 18-month old mice relative to the 12-month old mice (Ps＜0.05),and so did in the 12-month group relative to the 6-month group (Ps ＜0.05).The H3K9me3 levels in the DG and CA1 were positively correlated with the learning errors and latency,and the memory errors in the RAWM (Ps ＜0.05).There was no significant correlation between the performance of RAWM and the levels of H3K9me3 in CA3 (Ps ＞0.05).Our results suggested that the increased hippocampal H3K9me3 might be involved in the age-related impairment of spatial learning and memory in CD-1 mice.关键词
小鼠/衰老/H3K9三甲基化/学习记忆Key words
mouse/aging/H3K9me3/learning and memory分类
医药卫生引用本文复制引用
吴子幸,曹磊,王芳,陈贵海..CD-1小鼠海马H3K9三甲基化水平的年龄化改变及其与认知功能改变的相关性研究[J].安徽农业大学学报,2018,45(1):45-49,5.基金项目
国家青年自然科学基金(81301094)和国家自然科学基金(81370444)共同资助. （81301094）
