安徽农业大学学报2018，Vol.45Issue(1)：145-148,4.DOI:10.13610/j.cnki.1672-352x.20180302.016
新型大豆苷元萘磺酸酯的合成
Design and synthesis of daidzein naphthalene sulfonic acid esters
摘要
Abstract
In order to improve the inhibitory activity of daidzein on the abnormal proliferation of vascular smooth muscle cells,we designed and synthesized a series of daidzein naphthalene sulfonic acid ester derivatives based on the principles of kinetophore transformation,and their structures were characterized by IR,MS,elemental analysis and 1H NMR spectral data.The synthesis process of key intermediate 2 was optimized in five aspects of time,temperature,the ratio of reactants,the ratio of solvent to catalyst,and the ratio of reactant to catalyst.These compounds could be further employed to inhibit the abnormal proliferation of vascular smooth muscle cells.关键词
大豆苷元/萘磺酸酯/合成Key words
daidzein/naphthalene sulfonic acid ester/synthesis分类
化学化工引用本文复制引用
彭游,许冬民,徐菲菲,曲伟红..新型大豆苷元萘磺酸酯的合成[J].安徽农业大学学报,2018,45(1):145-148,4.基金项目
国家自然科学基金(81160412,81660541)和江西省自然科学基金(20132BAB204003)共同资助. （81160412,81660541）
