临床口腔医学杂志2018，Vol.34Issue(4)：202-205,4.DOI:10.3969/j.issn.1003-1634.2018.04.004
IBP促进人涎腺腺样囊性癌细胞侵袭和上皮间质转化的研究
IBP promotes invasion and epithelial?mesenchymal transition in salivary adenoid cystic carcinoma
摘要
Abstract
Objective: To investigate the effect of interferon regulatory factor-4 binding protein(IBP)on invasion and epithelial-mesenchymal transition in salivary adenoid cystic carcinoma cells.Methods:The ability of cell invasion was based on analysis of stained-cells penetrating study by Transwell experiments to determine the effects of IBP on the ability of cell invasion.The staining intensity of ACC2-C1/IBP and ACC2-C1 cells was observed and compared by the vimentin and ck8 immunofluorescence stain.Results:The invasion rate of ACC2-C1/IBP cells was higher than that of ACC2-C1 cells and ACC2 cells.The staining of ACC2-C1/IBP cells in vimentin was stronger than that in ACC2-C1 cells,and the staining of ACC2-C1/IBP cells in ck8 was weaker than that in ACC2-C1 cells.Conclusion:IBP can promote SACC cells invasion,and it was preliminary confirmed that IBP can promote the occurrence of epithelial-mesenchymal transition.关键词
干扰素调节因子-4结合蛋白(IBP)/腺样囊性癌(SACC)/上皮间质转化(EMT)Key words
Interferon regulatory factor-4 binding protein(IBP)/Salivary adenoid cystic carcinoma(SACC)/Epi-thelial-mesenchymal transition(EMT)分类
医药卫生引用本文复制引用
熊剑,李鹏,范舒,申涛,简从相,胡川闽,周继祥..IBP促进人涎腺腺样囊性癌细胞侵袭和上皮间质转化的研究[J].临床口腔医学杂志,2018,34(4):202-205,4.基金项目
国家自然科学基金(30901458) （30901458）
重庆市自然科学基金(CSTC2009BB5027) （CSTC2009BB5027）
