临床输血与检验2018，Vol.20Issue(2)：199-201,3.DOI:10.3969/j.issn.1671-2587.2018.02.029
冻干冷沉淀的制备与效果分析
Preparation and Effect Evaluation of Freeze-dried Cryoprecipitate
摘要
Abstract
Objective To research the method of freeze-dried cryoprecipitate and evaluate its effect. Methods Forty units of fresh whole blood (200ml) were collected from volunteer donors. Two bags of cryoprecipitate with same capacity were prepared from each unit of whole blood by conventional method,one bag was stored at–20℃ as frozen cryoprecipitate, and the other was prepared into freeze-dried cryoprecipitate after adding Compound Amino Acid Injection by lyophilizer and stored at 4℃. Two sets of cryoprecipitates from 20 donors were taken out and analyzed for factor Ⅷ,fibrinogen,and pH after 24 h,and the other cryoprecipitates were evaluated after 12 months. Results There are no significant differences of factor Ⅷ,fibrinogen,and pH between frozen and freeze-dried cryoprecipitate after 24 hours,and 12 months storage, respectively (P>0.05). Conclusion The freeze-dried cryoprecipitate stored at 4℃ after 12 months remain normal factor Ⅷand fibrinogen contents and can be used as blood reserve for wartime.关键词
冻干冷沉淀/因子Ⅷ/纤维蛋白原Key words
Freeze-dried cryoprecipitate/Factor Ⅷ/Fibrinogen分类
医药卫生引用本文复制引用
赵广超,李娜,王淑君,栾建凤,朱培元..冻干冷沉淀的制备与效果分析[J].临床输血与检验,2018,20(2):199-201,3.基金项目
本课题受全军重大科研课题(No.ANJ13J001),南京军区南京总医院科研基金(No.YYMS2014012)资助 （No.ANJ13J001）
