环境与职业医学2018，Vol.35Issue(3)：203-208,6.DOI:10.13213/j.cnki.jeom.2018.17525
克拉玛依油田工人职业紧张与ADD1基因对高血压患病率的影响
Effects of occupational stress and ADD1 gene on prevalence of hypertension in Karamay oilfield workers
摘要
Abstract
[Objective] To investigate the effects of occupational stress and ADD1 gene on the prevalence of hypertension in Karamay oilfield workers.[Methods] A total of 1300 oilfield workers in Karamay were selected by random cluster sampling method and investigated using Occupational Stress Inventory-Revised (the number of valid questionnaire was 1233,and the valid rate was 94.8％).Blood samples were collected from 352 oilfield workers (176 hypertension cases and 176 controls) to extract DNA and detect the genotypes of rs17833172 and rs4961 in ADD1 gene by polymerase chain reaction-restrictive fragment length polymorphism method.[Results] There was a higher score of occupational role in Karamay oilfield workers (168.28 ± 34.19) than that of the domestic norm (162.89 ± 27.04) (P＜0.05).The prevalence rate of hypertension increased with higher occupational stress levels (x2trend=13.82,P＜0.05),and the prevalence rate was higher in the high-stress group (18.49％) than in the low-stress group (1.54％) and the middle-stress group (5.51％).Among the blood samples of 352 oilfield workers,the genotypes of rs4961 varied among groups categorized by gender,age,and working years between the hypertension case group and the control group (Ps ＜ 0.05).The multi-factor logistic regression analysis results showed that higher personal coping resources (OR=0.989,95％CI:0.979-0.998) and TT genotype of rs4961 (OR=0.455,95％CI:0.244-0.846) were protective factors for hypertension,while GG genotype of rs17833172 (OR=3.113,95％CI:1.402-6.916) was a risk factor (P＜0.05).[Conclusion] Oilfield workers' hypertension may result from multi-sourced pathogens related to genes or occupational stress.Higher personal coping resources and rs4961 TT genotype of ADD1 gene may associate with a lower risk of hypertension in the oilfield workers,while rs17833172 GG genotype may associate with a higher risk of hypertension.关键词
油田工人/职业紧张/ADD1基因/高血压Key words
oilfield worker/occupational stress/ADD1 gene/hypertension分类
医药卫生引用本文复制引用
付爱玲,陶宁,葛华,张馨怡,刘继文..克拉玛依油田工人职业紧张与ADD1基因对高血压患病率的影响[J].环境与职业医学,2018,35(3):203-208,6.基金项目
国家自然科学基金(编号:81460489) （编号:81460489）
新疆维吾尔自治区研究生科研创新项目(编号:XJGRI2016082) （编号:XJGRI2016082）
