同济大学学报（医学版）2018，Vol.39Issue(1)：29-33,5.DOI:10.16118/j.1008-0392.2018.01.007
AEP小分子抑制剂compound#11对小鼠脊髓损伤的修复作用
Effect of AEP small molecule inhibitor compound #11 on repairing of spinal cord injury
摘要
Abstract
Objective To investigate the effect of AEP small molecule inhibitor compound # 11 on repairing of spinal cord injury in mice.Methods Twenty-eight healthy female C57BL/6 mice were equally divided into 4 groups:compound # 11 group,VPA group,saline control group and sham operation group.Spinal cord injury was induced by modified arterial clamp method in all groups except sham operation group.The compound #11,valproic acid and normal saline were given by intraperitoneal injection in compound #11,VPA and saline control groups,respectively.BMS scores and Rotarod scores were evaluated at 7,14,21 and 28 days after operation.The spinal cord tissue samples were taken for H-E staining and immunofluorescence staining.The integrity of spinal cord conduction function was assessed by motor evoked potential.Results Compared with saline control group,the motor function recovery was better in mice of compound#11 group and VPA group (P＜0.05).The proliferation of glial cells,the scar formation and apoptosis of neuronal cells in compound#11 group and VPA group were less marked than those in saline control group.The electrophysiological examination showed that the amplitude of compound#11 group,the VPA group,saline group were increased gradually,the latency was shortened,but there were no significant differences among three groups.Conclusion Compound #11 alone may have certain effect in repair of spinal cord injury,but the efficacy need to be further improved.关键词
脊髓损伤/小分子药物/神经保护Key words
spinal cord injuries/small molecule drug/neuroprotection分类
医药卫生引用本文复制引用
林升,罗丹丹,李琛,孙毅..AEP小分子抑制剂compound#11对小鼠脊髓损伤的修复作用[J].同济大学学报（医学版）,2018,39(1):29-33,5.基金项目
国家自然科学基金(31620103904) （31620103904）
