同济大学学报（医学版）2018，Vol.39Issue(1)：98-102,5.DOI:10.16118/j.1008-0392.2018.01.019
不同分级慢性阻塞性肺疾病患者合并骨质疏松症的相关因素分析
Risk factors of osteoporosis in patients with different grades of chronic obstructive pulmonary disease
居旭 1梁永杰 2汪进益1
作者信息
- 1. 同济大学附属东方医院呼吸科,上海200120
- 2. 上海市静安区闸北中心医院呼吸内科,上海200070
- 折叠
摘要
Abstract
Objective To analyze the risk factors of osteopenia and osteoporosis in patients with different grades of chronic obstructive pulmonary disease (COPD).Methods Sixty-three male patients with stable COPD were enrolled in the study.The bone mineral density of left femoral neck was measured by dual-energy X-ray absorptiometry (DXA).The quality of life of patients was assessed with COPD Assessment Test (CAT) questionnaire.The lung function was measured and graded according to Global Initiative for Chronic Obstructive Lung Disease (GOLD).Arterial blood gas and body mass index (BMI) were measured,and the age and smoking amount were recorded.Sixty-three healthy males were selected as control group.Results There was no significant difference in the incidence of osteopenia and osteoporosis between grade 2 COPD patients and controls.The incidence of osteopenia and osteoporosis in grades 3 and 4 patients was higher than that in the control group (P＜0.05).Logistic regression analysis showed that low BMI,low FEV1％pred and high CAT score were the risk factors of osteoporosis in COPD patients (OR =0.656,0.885,1.209,respectively;all P＜0.01).Conclusion The decrease of bone mineral density in COPD patients is related to air flow limitation,low body mass index and poor quality of life.关键词
慢性阻塞性肺疾病/骨质疏松症/慢性阻塞性肺疾病评估测试/相关性/危险因素Key words
chronic obstructive pulmonary disease/osteoporosis/chronic obstructive pulmonary disease/assessment test/relevance/risk factor分类
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居旭,梁永杰,汪进益..不同分级慢性阻塞性肺疾病患者合并骨质疏松症的相关因素分析[J].同济大学学报（医学版）,2018,39(1):98-102,5.
