生殖医学杂志2018，Vol.27Issue(4)：310-315,6.DOI:10.3969/j.issn.1004-3845.2018.04.004
早卵泡期长方案血清LH低的患者添加r-LH的临床结局分析
Clinical outcome of r-LH supplementation in patients with lower serum LH level in the long down-regulation protocol of early follicular phase
摘要
Abstract
Objective:To explore the effect of recombinant LH (r-LH)supplementation in patients with lower serum LH level in the long down-regulation protocol of early follicular phase on the pregnancy outcome.Methods:The data of patients undergone IVF/ICSI-ET treatment(1 331 cycles)in Jiangxi Province Maternal and Child Health Hospital from January 2013 to December 2015 were retrospectively analyzed.The patients were divided into the observation group (n =642) and control group (n =689) according to whether r-LH was supplemented on the 8th day after ovulation induction.The patients in the observation group were daily supplemented r-LH from Day 8 to HCG injection days.The patients in the control group did not add r-LH,only stimulated with FSH to HCG injection day.The live birth rate,embryo implantation rate,clinical pregnancy rate were compared between the two groups.Results:The levels of FSH,LH,E2,LH levels and endometrial thickness on HCG day,gonadotropin (Gn)days and total Gn dosage had no statistical difference between the two groups(P＞0.05).The levels of progesterone and E2 on HCG day in observation group were significantly lower than those in control group(P＜0.01).The number of oocytes retrieved,the average number of frozen embryos per cycle and the rate of whole embryo freezing in the observation group were significantly lower than those in the control group(P＜0.01).The M Ⅱ oocyte rate,implantation rate,clinical pregnancy rate,the live birth rate in each cycle in the observation group were slightly higher than the control group,but no significant difference(P＞0.05).Conclusions:For patients with over-repression LH levels(LH≤0.5 U/L) during ovulation induction with a long protocol in early follicular phase,supplementation of r-LH tends to increase clinical pregnancy rates but still requires a larger sample size prospective study to validate.关键词
重组人黄体生成素/体外受精-胚胎移植/促性腺激素释放激素激动剂/临床妊娠率Key words
Recombinant LH/IVF/ICSI-ET/GnRH agonist/Clinical pregnancy rate引用本文复制引用
田莉峰,伍琼芳,谭俊,苏琼,李游,许定飞..早卵泡期长方案血清LH低的患者添加r-LH的临床结局分析[J].生殖医学杂志,2018,27(4):310-315,6.基金项目
江西省科技厅计划项目(20151BBG70100) （20151BBG70100）
