生殖医学杂志2018，Vol.27Issue(4)：335-338,4.DOI:10.3969/j.issn.1004-3845.2018.04.008
冻融胚胎移植对妊娠早期胚胎流产率的影响
Influence of frozen-thawed embryo transfer on abortion rate at early pregnancy
摘要
Abstract
Objective:To study weather frozen-thawed embryo transfer increase abortion rate comparing with fresh embryo transfer.Methods:A retrospective analysis was conducted on the clinical data of 6 834 clinical pregnancy patients undergone IVF,including 4 212 fresh embryo transfer cycles and 2 262 frozen-thawed embryo transfer cycles.The first trimester miscarriage rate,abortion rate and live birth rate were compared between fresh embryo transfer group and frozen embryo transfer group.In addition,the embryos transferred were divided into cleavage stage transfer group(Day 3 group)and blastocyst transfer group(Day 5 group)according to the stage of embryo transferred.The first trimester miscarriage rate,abortion rate and live birth rate were compared between fresh embryo transfer and frozen embryo transfer in the Day 3 group,as well as in the Day 5 group.Results:There was no significant difference in age and infertility duration between fresh embryo group and frozen embryo group(P＞0.05).The first trimester miscarriage rate(18.9％ vs.24.3％)and abortion rate(14.4％ vs.17.1％)were significantly lower,but the live birth rate(85.6％ vs.82.9％)was significantly higher in fresh embryo transfer group than that in frozen embryo transfer group(P＜0.05).There were significantly differences in the first trimester miscarriage rate(19.4％ vs.30.0％),abortion rate(14.5％ vs.19.6％)and live birth rate(85.5％ vs.80.4％)between fresh embryo transfer and frozen embryo transfer in Day 3 group(P＜0.05).However,there were no significantly differences in the first trimester miscarriage rate(17.0 ％ vs.20.2％),abortionrate(14.0％ vs.15.3％)and live birthrate(86.1％vs.84.7％)between fresh embryo transfer and frozen embryo transfer in Day 5 group(P＞0.05).Conclusions:The frozen-thawed embryo transfer may increase the first trimester miscarriage rate and abortion rat,but reduce the live birth rate comparing with fresh embryo transfer.Therefore,the fresh embryo transfer should be chosen firstly in the IVF cycle.If the frozen-thawed embryo transfer is chosen,it is better to select the blastocyst transfer.关键词
冻融胚胎移植/卵裂期胚胎/囊胚/流产率Key words
Frozen-thawed embryo transfer/Cleavage stage embryo/Blastocyst/Abortion rate引用本文复制引用
江成龙,张昌军..冻融胚胎移植对妊娠早期胚胎流产率的影响[J].生殖医学杂志,2018,27(4):335-338,4.基金项目
湖北医药学院重点学科建设经费项目(2014XKJSSJ08) （2014XKJSSJ08）
