中国组织工程研究2017，Vol.21Issue(36)：5757-5762,6.DOI:10.3969/j.issn.2095-4344.2017.36.004
基质细胞衍生因子1/CXC族细胞因子受体4信号轴对大鼠牙齿移动速率的影响
Role of stromal cell-derived factor 1/CXC chemokine receptor axis in rat tooth movement
摘要
Abstract
BACKGROUND:Orthodontic treatment has a long course and referral interval,which is an important difficulty.How to accelerate orthodontic tooth movement is an issue of concern.OBJECTIVE:To testify whether the local injection of AMD3100 (CXCR4 antagonist) can accelerate the tooth movement or not,and to explore the role of stromal cell-derived factor 1/CXC chemokine receptor axis in tooth movement.METHODS:Ninety Sprague-Dawley rats aged 8-10 weeks old were selected and the models of orthodontic tooth movement were established.The model rats were randomized into three groups,and then given the injection of stromal cell-derived factor 1,AMD3100 or PBS.The rats were killed at 1,3,5,7,10 and 14 days to measure the tooth movement distance.RESULTS AND CONCLUSION:The tooth movement distance showed difference among three groups;AMD3100 could facilitate the tooth movement,while stromal cell-derived factor 1 exerted inhibitory effect on the tooth movement.To conclude,stromal cell-derived factor 1/CXC chemokine receptor axis plays an important role in tooth movement.关键词
组织构建/骨组织工程/正畸牙移动/基质细胞衍生因子1/CXCR4/AMD3100分类
医药卫生引用本文复制引用
程钎,林富伟,谢乙加,黄跃,王军..基质细胞衍生因子1/CXC族细胞因子受体4信号轴对大鼠牙齿移动速率的影响[J].中国组织工程研究,2017,21(36):5757-5762,6.基金项目
泸州医学院青年基金(2014QN-050) （2014QN-050）
Youth Foundation of Luzhou Medical College,No.2014QN-050 （）
